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Ripa I, Andreu S, López-Guerrero JA, et al. Membrane Rafts: Portals for Viral Entry. Front Microbiol. 2021;12:631274doi: 10.3389/fmicb.2021.631274.
Ripa, I., Andreu, S., López-Guerrero, J. A., & Bello-Morales, R. (2021). Membrane Rafts: Portals for Viral Entry. Frontiers in microbiology, 12631274. https://doi.org/10.3389/fmicb.2021.631274
Ripa, Inés, et al. "Membrane Rafts: Portals for Viral Entry." Frontiers in microbiology vol. 12 (2021): 631274. doi: https://doi.org/10.3389/fmicb.2021.631274
Ripa I, Andreu S, López-Guerrero JA, Bello-Morales R. Membrane Rafts: Portals for Viral Entry. Front Microbiol. 2021 Feb 04;12:631274. doi: 10.3389/fmicb.2021.631274. eCollection 2021. PMID: 33613502; PMCID: PMC7890030.
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Front Microbiol. 2021 Feb 04;12:631274. doi: 10.3389/fmicb.2021.631274. eCollection 2021.

Membrane Rafts: Portals for Viral Entry.

Frontiers in microbiology

Inés Ripa, Sabina Andreu, José Antonio López-Guerrero, Raquel Bello-Morales

Affiliations

  1. Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain.
  2. Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.

PMID: 33613502 PMCID: PMC7890030 DOI: 10.3389/fmicb.2021.631274

Abstract

Membrane rafts are dynamic, small (10-200 nm) domains enriched with cholesterol and sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to the lifecycle of different viral families including virus entry, assembly and/or budding events. Rafts seem to participate in virus attachment and recruitment to the cell surface, as well as the endocytic and non-endocytic mechanisms some viruses use to enter host cells. In this review, we will introduce the specific role of rafts in viral entry and define cellular factors implied in the choice of one entry pathway over the others. Finally, we will summarize the most relevant information about raft participation in the entry process of enveloped and non-enveloped viruses.

Copyright © 2021 Ripa, Andreu, López-Guerrero and Bello-Morales.

Keywords: caveolae; cholesterol; endocytosis; raft; viral entry

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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