Display options
Cite
Krorakai K, Tontipattananon S, Leemahanil R, et al. Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers. Pract Lab Med. 2021;24:e00204doi: 10.1016/j.plabm.2021.e00204.
Krorakai, K., Tontipattananon, S., Leemahanil, R., Klangphukhiew, S., Wongrathanandha, C., Phaibulpanich, A., & Patramanon, R. (2021). Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers. Practical laboratory medicine, 24e00204. https://doi.org/10.1016/j.plabm.2021.e00204
Krorakai, Karnpimon, et al. "Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers." Practical laboratory medicine vol. 24 (2021): e00204. doi: https://doi.org/10.1016/j.plabm.2021.e00204
Krorakai K, Tontipattananon S, Leemahanil R, Klangphukhiew S, Wongrathanandha C, Phaibulpanich A, Patramanon R. Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers. Pract Lab Med. 2021 Jan 18;24:e00204. doi: 10.1016/j.plabm.2021.e00204. eCollection 2021 Mar. PMID: 33553553; PMCID: PMC7848761.
Copy Download .nbib Format: NLM
Share it on

Pract Lab Med. 2021 Jan 18;24:e00204. doi: 10.1016/j.plabm.2021.e00204. eCollection 2021 Mar.

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers.

Practical laboratory medicine

Karnpimon Krorakai, Siriporn Tontipattananon, Rattikorn Leemahanil, Supannika Klangphukhiew, Chathaya Wongrathanandha, Akarin Phaibulpanich, Rina Patramanon

Affiliations

  1. Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  2. Department of Community Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  3. Department of Statistics, Faculty of Commerce and Accountancy, Chulalongkorn University, Bangkok, Thailand.
  4. Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Khon Kaen University, Khon Kaen, Thailand.

PMID: 33553553 PMCID: PMC7848761 DOI: 10.1016/j.plabm.2021.e00204

Abstract

OBJECTIVE: Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs levels with age and sex. Thus, this noninvasive, cross-sectional study aimed to investigate the correlation of urine DHEAs levels with age and sex in healthy Thai volunteers aged 20-80 years.

METHODS: DHEAs levels were measured in 178 healthy volunteers using electrochemiluminescence immunoassay and then normalized by creatinine. Multiple regression was performed to determine the correlation of urine DHEAs levels normalized by creatinine with age and sex.

RESULTS: The normalized DHEAs levels are correlated with age group for both sexes. Moreover, an increasing trend in DHEAs levels was found in the age group 20-29 years, and the DHEAs level peaked at the age group 30-39 years before declining with advancing age. Based on the multiple regression analyses, the significance of the interaction term (

CONCLUSION: This study reports more data on clinical reference value of urine DHEAs levels in healthy volunteers. Our result demonstrates urine DHEAs levels are associated with age and sex and decline by 2-3% a year.

© 2021 The Author(s).

Keywords: Age; Dehydroepiandrosterone sulfate; Sex; Urine

References

  1. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4279-84 - PubMed
  2. Hypertension. 1990 Oct;16(4):462-7 - PubMed
  3. Psychiatry Res. 2015 Sep 30;229(1-2):447-53 - PubMed
  4. Calcif Tissue Int. 2011 Oct;89(4):295-302 - PubMed
  5. Arch Gerontol Geriatr. 2009 Jul-Aug;49(1):7-12 - PubMed
  6. J Clin Endocrinol Metab. 1992 Oct;75(4):1002-4 - PubMed
  7. J Clin Endocrinol Metab. 1999 May;84(5):1527-33 - PubMed
  8. Yonsei Med J. 2007 Jun 30;48(3):379-88 - PubMed
  9. J Clin Endocrinol Metab. 1996 Sep;81(9):3147-51 - PubMed
  10. J Am Heart Assoc. 2017 May 5;6(5): - PubMed
  11. J Clin Endocrinol Metab. 1978 Sep;47(3):572-7 - PubMed
  12. Aging Clin Exp Res. 2012 Apr;24(2):134-8 - PubMed
  13. J Clin Endocrinol Metab. 1996 Mar;81(3):1173-8 - PubMed
  14. Clin Endocrinol (Oxf). 1983 Jul;19(1):117-29 - PubMed
  15. Hum Reprod Update. 2007 May-Jun;13(3):239-48 - PubMed
  16. Clin Exp Immunol. 1999 Sep;117(3):476-81 - PubMed
  17. J Clin Endocrinol Metab. 1997 Aug;82(8):2396-402 - PubMed
  18. N Engl J Med. 1999 Sep 30;341(14):1013-20 - PubMed
  19. J Clin Endocrinol Metab. 2005 Apr;90(4):2015-21 - PubMed
  20. J Clin Endocrinol Metab. 2000 Dec;85(12):4650-6 - PubMed
  21. J Clin Endocrinol Metab. 1978 Mar;46(3):396-401 - PubMed
  22. Gen Comp Endocrinol. 2000 Mar;117(3):427-38 - PubMed
  23. J Endocrinol Invest. 2009 Oct;32(9):766-72 - PubMed
  24. Ann Rheum Dis. 2004 Aug;63(8):961-8 - PubMed
  25. Steroids. 1994 Jan;59(1):10-5 - PubMed
  26. Exp Gerontol. 1998 Nov-Dec;33(7-8):897-910 - PubMed

Publication Types