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Rüeger S, Hammer C, Loetscher A, et al. The influence of human genetic variation on Epstein-Barr virus sequence diversity. Sci Rep. 2021;11(1):4586doi: 10.1038/s41598-021-84070-7.
Rüeger, S., Hammer, C., Loetscher, A., McLaren, P. J., Lawless, D., Naret, O., Khanna, N., Bernasconi, E., Cavassini, M., Günthard, H. F., Kahlert, C. R., Rauch, A., Depledge, D. P., Morfopoulou, S., Breuer, J., Zdobnov, E., Fellay, J. (2021). The influence of human genetic variation on Epstein-Barr virus sequence diversity. Scientific reports, 11(1), 4586. https://doi.org/10.1038/s41598-021-84070-7
Rüeger, Sina, et al. "The influence of human genetic variation on Epstein-Barr virus sequence diversity." Scientific reports vol. 11,1 (2021): 4586. doi: https://doi.org/10.1038/s41598-021-84070-7
Rüeger S, Hammer C, Loetscher A, McLaren PJ, Lawless D, Naret O, Khanna N, Bernasconi E, Cavassini M, Günthard HF, Kahlert CR, Rauch A, Depledge DP, Morfopoulou S, Breuer J, Zdobnov E, Fellay J. The influence of human genetic variation on Epstein-Barr virus sequence diversity. Sci Rep. 2021 Feb 25;11(1):4586. doi: 10.1038/s41598-021-84070-7. PMID: 33633271; PMCID: PMC7907281.
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Sci Rep. 2021 Feb 25;11(1):4586. doi: 10.1038/s41598-021-84070-7.

The influence of human genetic variation on Epstein-Barr virus sequence diversity.

Scientific reports

Sina Rüeger, Christian Hammer, Alexis Loetscher, Paul J McLaren, Dylan Lawless, Olivier Naret, Nina Khanna, Enos Bernasconi, Matthias Cavassini, Huldrych F Günthard, Christian R Kahlert, Andri Rauch, Daniel P Depledge, Sofia Morfopoulou, Judith Breuer, Evgeny Zdobnov, Jacques Fellay,

Affiliations

  1. School of Life Sciences, EPFL, Lausanne, Switzerland.
  2. Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  3. Genentech Inc, 1 DNA Way, South San Francisco, CA, USA.
  4. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  5. JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB, Canada.
  6. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
  7. Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  8. Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
  9. Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
  10. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  11. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St.Gallen, St.Gallen, Switzerland.
  12. Childrens Hospital of Eastern Switzerland, St. Gallen, Switzerland.
  13. Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
  14. Division of Infection and Immunity, University College London, London, UK.
  15. School of Life Sciences, EPFL, Lausanne, Switzerland. [email protected].
  16. Swiss Institute of Bioinformatics, Lausanne, Switzerland. [email protected].
  17. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. [email protected].

PMID: 33633271 PMCID: PMC7907281 DOI: 10.1038/s41598-021-84070-7

Abstract

Epstein-Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm

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