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Eur Heart J Cardiovasc Imaging. 2021 Mar 22;22(4):397-405. doi: 10.1093/ehjci/jeaa351.

Cardiac computed tomography in cardio-oncology: an update on recent clinical applications.

European heart journal. Cardiovascular Imaging

Stefania Rosmini, Ankita Aggarwal, Daniel H Chen, John Conibear, Ceri L Davies, Amit Kumar Dey, Paula Edwards, Avirup Guha, Arjun K Ghosh

Affiliations

  1. Cardiology Department, Barts Heart Centre, St Bartholomew's Hospital, London EC1A 7BE, UK.
  2. Department of Internal Medicine, Wayne State University, Providence Hospital, Rochester, MI, USA.
  3. Cardio-Oncology Service, University College London Hospital, London, UK.
  4. Hatter Cardiovascular Institute, University College London, London, UK.
  5. Oncology Department, Barts Cancer Centre, St Bartholomew's Hospital London, UK.
  6. National Heart, Lung and Blood Institute, Bethesda, USA.
  7. Department of Internal Medicine, Georgetown University, Washington, DC, USA.
  8. Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  9. Harrington Heart and Vascular Institute, Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA.

PMID: 33555007 PMCID: PMC8453276 DOI: 10.1093/ehjci/jeaa351

Abstract

Chemotherapy and radiotherapy have drastically improved cancer survival, but they can result in significant short- and long-term cardiovascular complications, most commonly heart failure from chemotherapy, whilst radiotherapy increases the risk of premature coronary artery disease (CAD), valve, and pericardial diseases. Cardiac computed tomography (CT) with calcium scoring has a role in screening asymptomatic patients for premature CAD, cardiac CT angiography (CTCA) allows the identification of significant CAD, also in the acute settings where concerns exist towards invasive angiography. CTCA integrates the diagnostic work-up and guides surgical/percutaneous management of valvular heart diseases and allows the assessment of pericardial conditions, including detection of effusion and pericardial calcification. It is a widely available and fast imaging modality that allows a one-step evaluation of CAD, myocardial, valvular, and pericardial disease. This review aims to provide an update on its current use and accompanying evidence-base for cardiac CT in the management of cardio-oncology patients.

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: [email protected].

Keywords: cardiac CT; cardio-oncology; coronary artery disease; pericardial disease; valvular disease

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