Display options
Cite
McKenna MJ, Crowley RK, Twomey PJ, et al. Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium. JBMR Plus. 2020;5(2):e10437doi: 10.1002/jbm4.10437.
McKenna, M. J., Crowley, R. K., Twomey, P. J., & Kilbane, M. T. (2021). Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium. JBMR plus, 5(2), e10437. https://doi.org/10.1002/jbm4.10437
McKenna, Malachi J, et al. "Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium." JBMR plus vol. 5,2 (2021): e10437. doi: https://doi.org/10.1002/jbm4.10437
McKenna MJ, Crowley RK, Twomey PJ, Kilbane MT. Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium. JBMR Plus. 2020 Dec 09;5(2):e10437. doi: 10.1002/jbm4.10437. eCollection 2021 Feb. PMID: 33615106; PMCID: PMC7872336.
Copy Download .nbib Format: NLM
Share it on

JBMR Plus. 2020 Dec 09;5(2):e10437. doi: 10.1002/jbm4.10437. eCollection 2021 Feb.

Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium.

JBMR plus

Malachi J McKenna, Rachel K Crowley, Patrick J Twomey, Mark T Kilbane

Affiliations

  1. UCD School of Medicine University College Dublin Dublin Ireland.
  2. Department of Clinical Chemistry St. Vincent's University Hospital Dublin Ireland.
  3. Department of Endocrinology St. Vincent's University Hospital Dublin Ireland.

PMID: 33615106 PMCID: PMC7872336 DOI: 10.1002/jbm4.10437

Abstract

Excess fibroblast growth factor 23 (FGF23), excess PTH, and an increase in extracellular calcium cause hypophosphatemia by lowering the maximum renal phosphate reabsorption threshold (TmP/GFR). We recently reported two cases of X-linked hypophosphatemia (XLH) with severe tertiary hyperparathyroidism who had normalization of TmP/GFR upon being rendered hypoparathyroid following total parathyroidectomy, despite marked excess in both C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23). We explored the effects of FGF23, PTH, and calcium on TmP/GFR in a cross-sectional study (

© 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.

Keywords: FIBROBLAST GROWTH FACTOR 23; HYPERPARATHYROIDISM; HYPOPARATHYROIDISM; PARATHYROID HORMONE; X‐LINKED HYPOPHOSPHATEMIA

References

  1. J Bone Miner Res. 2018 Aug;33(8):1383-1393 - PubMed
  2. J Med Case Rep. 2014 Mar 04;8:84 - PubMed
  3. Osteoporos Int. 2018 Nov;29(11):2369-2387 - PubMed
  4. J Clin Endocrinol Metab. 2014 Sep;99(9):3103-11 - PubMed
  5. N Engl J Med. 1980 Dec 11;303(24):1377-83 - PubMed
  6. Clin Sci. 1969 Aug;37(1):23-36 - PubMed
  7. J Bone Miner Metab. 2019 Jul;37(4):685-693 - PubMed
  8. J Bone Miner Res. 2004 Mar;19(3):429-35 - PubMed
  9. Acta Paediatr. 2020 Jul;109(7):1491-1492 - PubMed
  10. N Engl J Med. 1969 Oct 2;281(14):762-6 - PubMed
  11. Clin Chem Lab Med. 2020 Jan 28;58(2):197-201 - PubMed
  12. J Clin Endocrinol Metab. 1985 Apr;60(4):711-7 - PubMed
  13. J Am Soc Nephrol. 2005 Jul;16(7):2205-15 - PubMed
  14. J Bone Miner Res. 1994 Nov;9(11):1723-8 - PubMed
  15. J Clin Endocrinol Metab. 2012 Mar;97(3):696-706 - PubMed
  16. Clin Chim Acta. 1969 Oct;26(1):15-24 - PubMed
  17. Ann Intern Med. 1968 Mar;68(3):553-60 - PubMed
  18. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11418-11427 - PubMed
  19. J Bone Miner Res. 2019 Dec;34(12):2183-2191 - PubMed
  20. Osteoporos Int. 2020 Jul;31(7):1395-1398 - PubMed
  21. Calcif Tissue Int. 2018 Mar;102(3):321-328 - PubMed
  22. J Clin Invest. 1985 Dec;76(6):2403-12 - PubMed
  23. Science. 1972 Mar 3;175(4025):997-1000 - PubMed
  24. Bone. 2019 Oct;127:386-392 - PubMed
  25. Am J Physiol Renal Physiol. 2009 Aug;297(2):F282-91 - PubMed
  26. J Bone Miner Res. 2020 Jul;35(7):1263-1273 - PubMed
  27. JAMA. 2020 Feb 4;323(5):432-443 - PubMed
  28. J Clin Endocrinol Metab. 2013 Nov;98(11):4273-8 - PubMed
  29. Endocrinology. 2007 Oct;148(10):4974-83 - PubMed
  30. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):450-6 - PubMed
  31. J Bone Miner Res. 2007 Jun;22(6):931-7 - PubMed
  32. J Clin Endocrinol Metab. 2004 Sep;89(9):4489-92 - PubMed
  33. Miner Electrolyte Metab. 1986;12(2):119-24 - PubMed
  34. Kidney Int. 2018 May;93(5):1073-1085 - PubMed
  35. J Bone Miner Res. 2020 Feb;35(2):231-238 - PubMed
  36. Curr Osteoporos Rep. 2013 Jun;11(2):65-71 - PubMed
  37. Sci Rep. 2019 May 6;9(1):6974 - PubMed
  38. N Engl J Med. 2018 May 24;378(21):1987-1998 - PubMed
  39. Aliment Pharmacol Ther. 2019 Aug;50(4):397-406 - PubMed
  40. J Bone Miner Res. 2011 Jul;26(7):1381-8 - PubMed
  41. Int J Endocrinol. 2015;2015:872193 - PubMed

Publication Types