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Apfel V, Begue D, Cordo' V, et al. Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms. ACS Pharmacol Transl Sci. 2021;4(1):327-337doi: 10.1021/acsptsci.0c00196.
Apfel, V., Begue, D., Cordo', V., Holzer, L., Martinuzzi, L., Buhles, A., Kerr, G., Barbosa, I., Naumann, U., Piquet, M., Ruddy, D., Weiss, A., Ferretti, S., Almeida, R., Bonenfant, D., Tordella, L., & Galli, G. G. (2021). Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms. ACS pharmacology & translational science, 4(1), 327-337. https://doi.org/10.1021/acsptsci.0c00196
Apfel, Verena, et al. "Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms." ACS pharmacology & translational science vol. 4,1 (2021): 327-337. doi: https://doi.org/10.1021/acsptsci.0c00196
Apfel V, Begue D, Cordo' V, Holzer L, Martinuzzi L, Buhles A, Kerr G, Barbosa I, Naumann U, Piquet M, Ruddy D, Weiss A, Ferretti S, Almeida R, Bonenfant D, Tordella L, Galli GG. Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms. ACS Pharmacol Transl Sci. 2021 Jan 13;4(1):327-337. doi: 10.1021/acsptsci.0c00196. eCollection 2021 Feb 12. PMID: 33615182; PMCID: PMC7887857.
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ACS Pharmacol Transl Sci. 2021 Jan 13;4(1):327-337. doi: 10.1021/acsptsci.0c00196. eCollection 2021 Feb 12.

Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.

ACS pharmacology & translational science

Verena Apfel, Damien Begue, Valentina Cordo', Laura Holzer, Laetitia Martinuzzi, Alexandra Buhles, Grainne Kerr, Ines Barbosa, Ulrike Naumann, Michelle Piquet, David Ruddy, Andreas Weiss, Stephane Ferretti, Reinaldo Almeida, Debora Bonenfant, Luca Tordella, Giorgio G Galli

Affiliations

  1. Disease area Oncology, Novartis Institute for Biomedical Research, Basel, Switzerland.
  2. Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.
  3. Disease area Oncology, Novartis Institute for Biomedical Research, Cambridge, Massachusetts 02139United States.
  4. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland.

PMID: 33615182 PMCID: PMC7887857 DOI: 10.1021/acsptsci.0c00196

Abstract

Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (

© 2021 American Chemical Society.

Conflict of interest statement

The authors declare the following competing financial interest(s): Authors affiliated to Novartis Institute for Biomedical Research are employees of Novartis Pharma AG.

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