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PeerJ. 2021 Feb 01;9:e10280. doi: 10.7717/peerj.10280. eCollection 2021.

The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype.

PeerJ

Patrick B Thomas, Penny Jeffery, Manuel D Gahete, Eliza Whiteside, Carina Walpole, Michelle Maugham, Lidija Jovanovic, Jennifer Gunter, Elizabeth Williams, Colleen Nelson, Adrian Herington, Raul M Luque, Rakesh Veedu, Lisa K Chopin, Inge Seim

Affiliations

  1. Ghrelin Research Group, Translational Research Institute, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  2. Comparative and Endocrine Biology Laboratory, Translational Research Institute, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
  3. Australian Prostate Cancer Research Centre - Queensland, Queensland University of Technology, Brisbane, Queensland, Australia.
  4. Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain.
  5. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
  6. Hospital Universitario Reina Sofía (HURS), Cordoba, Spain.
  7. Campus de Excelencia Internacional Agroalimentario (ceiA3), Cordoba, Spain.
  8. CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Cordoba, Spain.
  9. Centre for Health Research, University of Southern Queensland, Toowoomba, Queensland, Australia.
  10. Institute for Life Sciences and the Environment, University of Southern Queensland, Toowoomba, Queensland, Australia.
  11. Centre for Comparative Genomics, Murdoch University, Perth, Western Australia, Australia.
  12. Integrative Biology Laboratory, College of Life Sciences, Nanjing Normal University, Nanjing, China.

PMID: 33585078 PMCID: PMC7860111 DOI: 10.7717/peerj.10280

Abstract

It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized

©2021 Thomas et al.

Keywords: Antisense transcript; Gene expression; Long non-coding RNA; Prostate cancer; Tumour growth; lncRNA

Conflict of interest statement

The authors declare there are no competing interests.

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