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Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children-Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Front Pediatr. 2021;9:611680doi: 10.3389/fped.2021.611680.
Aran, A. A., Karam, O., & Nellis, M. E. (2021). Bleeding in Critically Ill Children-Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers in pediatrics, 9611680. https://doi.org/10.3389/fped.2021.611680
Aran, Adi Avniel, et al. "Bleeding in Critically Ill Children-Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation." Frontiers in pediatrics vol. 9 (2021): 611680. doi: https://doi.org/10.3389/fped.2021.611680
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children-Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Front Pediatr. 2021 Jan 27;9:611680. doi: 10.3389/fped.2021.611680. eCollection 2021. PMID: 33585373; PMCID: PMC7873638.
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Front Pediatr. 2021 Jan 27;9:611680. doi: 10.3389/fped.2021.611680. eCollection 2021.

Bleeding in Critically Ill Children-Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation.

Frontiers in pediatrics

Adi Avniel Aran, Oliver Karam, Marianne E Nellis

Affiliations

  1. Pediatric Cardiac Critical Care Division, Hadassah University Medical Center, Jerusalem, Israel.
  2. Division of Pediatric Critical Care Medicine, Children's Hospital of Richmond at VCU, Richmond, VA, United States.
  3. Pediatric Critical Care Medicine, NY Presbyterian Hospital-Weill Cornell Medicine, New York, NY, United States.

PMID: 33585373 PMCID: PMC7873638 DOI: 10.3389/fped.2021.611680

Abstract

Clinically significant bleeding complicates up to 20% of admissions to the intensive care unit in adults and is associated with severe physiologic derangements, requirement for significant interventions and worse outcome. There is a paucity of published data on bleeding in critically ill children. In this manuscript, we will provide an overview of the epidemiology and characteristics of bleeding in critically ill children, address the association between bleeding and clinical outcomes, describe the current definitions of bleeding and their respective limitations, and finally provide an overview of current knowledge gaps and suggested areas for future research.

Copyright © 2021 Aran, Karam and Nellis.

Keywords: bleeding; critical ill children; epidemiology; hemorrhage; scale

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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