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Hayashida K, Miyara SJ, Shinozaki K, et al. Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments. Front Med (Lausanne). 2021;7:586229doi: 10.3389/fmed.2020.586229.
Hayashida, K., Miyara, S. J., Shinozaki, K., Takegawa, R., Yin, T., Rolston, D. M., Choudhary, R. C., Guevara, S., Molmenti, E. P., & Becker, L. B. (2020). Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments. Frontiers in medicine, 7586229. https://doi.org/10.3389/fmed.2020.586229
Hayashida, Kei, et al. "Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments." Frontiers in medicine vol. 7 (2020): 586229. doi: https://doi.org/10.3389/fmed.2020.586229
Hayashida K, Miyara SJ, Shinozaki K, Takegawa R, Yin T, Rolston DM, Choudhary RC, Guevara S, Molmenti EP, Becker LB. Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments. Front Med (Lausanne). 2021 Jan 14;7:586229. doi: 10.3389/fmed.2020.586229. eCollection 2020. PMID: 33585501; PMCID: PMC7873953.
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Front Med (Lausanne). 2021 Jan 14;7:586229. doi: 10.3389/fmed.2020.586229. eCollection 2020.

Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments.

Frontiers in medicine

Kei Hayashida, Santiago J Miyara, Koichiro Shinozaki, Ryosuke Takegawa, Tai Yin, Daniel M Rolston, Rishabh C Choudhary, Sara Guevara, Ernesto P Molmenti, Lance B Becker

Affiliations

  1. Laboratory for Critical Care Physiology, Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, United States.
  2. Department of Emergency Medicine, North Shore University Hospital, Northwell Health System, Manhasset, NY, United States.
  3. Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, United States.
  4. Department of Surgery, Medicine, and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, New York, NY, United States.
  5. Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States.
  6. Department of Surgery, Northwell Health, Manhasset, NY, United States.
  7. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, NY, United States.

PMID: 33585501 PMCID: PMC7873953 DOI: 10.3389/fmed.2020.586229

Abstract

Despite recent advances in the management of post-cardiac arrest syndrome (PCAS), the survival rate, without neurologic sequelae after resuscitation, remains very low. Whole-body ischemia, followed by reperfusion after cardiac arrest (CA), contributes to PCAS, for which established pharmaceutical interventions are still lacking. It has been shown that a number of different processes can ultimately lead to neuronal injury and cell death in the pathology of PCAS, including vasoconstriction, protein modification, impaired mitochondrial respiration, cell death signaling, inflammation, and excessive oxidative stress. Recently, the pathophysiological effects of inhaled gases including nitric oxide (NO), molecular hydrogen (H

Copyright © 2021 Hayashida, Miyara, Shinozaki, Takegawa, Yin, Rolston, Choudhary, Guevara, Molmenti and Becker.

Keywords: PCAS; cardiac arrest; cardiopulmonary resuscitation; ischemia-reperfusion injury; molecular hydrogen (H2); neuroprotection; nitric oxide; xenon

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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