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Hao G, Halbert J, Su S, et al. Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass. Acta Cardiol. 2021;1-7doi: 10.1080/00015385.2020.1871262.
Hao, G., Halbert, J., Su, S., Bagi, Z., Robinson, V., Thayer, J., Harshfield, G., & Kapuku, G. (2021). Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass. Acta cardiologica, 1-7. https://doi.org/10.1080/00015385.2020.1871262
Hao, Guang, et al. "Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass." Acta cardiologica vol. (2021): 1-7. doi: https://doi.org/10.1080/00015385.2020.1871262
Hao G, Halbert J, Su S, Bagi Z, Robinson V, Thayer J, Harshfield G, Kapuku G. Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass. Acta Cardiol. 2021 Feb 09;1-7. doi: 10.1080/00015385.2020.1871262. Epub 2021 Feb 09. PMID: 33557704.
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Acta Cardiol. 2021 Feb 09;1-7. doi: 10.1080/00015385.2020.1871262. Epub 2021 Feb 09.

Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass.

Acta cardiologica

Guang Hao, James Halbert, Shayong Su, Zsolt Bagi, Vincent Robinson, Julian Thayer, Gregory Harshfield, Gaston Kapuku

Affiliations

  1. Georgia Prevention Institute, Departments of Medicine, Pediatrics, and Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  2. Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  3. Division of Cardiology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  4. Department of Psychology and Neurosciences, The Ohio State University, Columbus, OH, USA.

PMID: 33557704 DOI: 10.1080/00015385.2020.1871262

Abstract

BACKGROUND: Little is known about the varied resting heart rate (RHR) trajectory patterns from childhood to young adulthood and their clinical significance. We aim to identify RHR trajectories from childhood to young adulthood, and to determine their relationship with left ventricular mass (LVM) index.

METHODS: RHR was measured up to 15 times over a 21-year period in 759 participants from childhood to young adulthood. LVM was measured using echocardiography and was normalised to body surface area to obtain LVM index in 546 participants.

RESULTS: Using latent class models, three trajectory groups in RHR from childhood to young adulthood were identified, including high-decreasing group (HDG), moderate-decreasing group (MDG), and low-decreasing group (LDG). We found that trajectory of RHR was a significant predictor of LVM index with faster decrease of RHR associated with higher levels of total peripheral resistance (

CONCLUSION: Our findings show an association between RHR trajectories from childhood to young adulthood with cardiac mass, suggesting that monitoring RHR may help identify subpopulation at high cardiovascular risk.

Keywords: Resting heart rate trajectories; ethnicity; left ventricular mass; longitudinal study; total peripheral resistance index; youth cohort

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