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Valomon A, Riedner BA, Jones SG, et al. A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder. Sci Rep. 2021;11(1):4758doi: 10.1038/s41598-021-83980-w.
Valomon, A., Riedner, B. A., Jones, S. G., Nakamura, K. P., Tononi, G., Plante, D. T., Benca, R. M., & Boly, M. (2021). A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder. Scientific reports, 11(1), 4758. https://doi.org/10.1038/s41598-021-83980-w
Valomon, Amandine, et al. "A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder." Scientific reports vol. 11,1 (2021): 4758. doi: https://doi.org/10.1038/s41598-021-83980-w
Valomon A, Riedner BA, Jones SG, Nakamura KP, Tononi G, Plante DT, Benca RM, Boly M. A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder. Sci Rep. 2021 Feb 26;11(1):4758. doi: 10.1038/s41598-021-83980-w. PMID: 33637812; PMCID: PMC7910582.
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Sci Rep. 2021 Feb 26;11(1):4758. doi: 10.1038/s41598-021-83980-w.

A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder.

Scientific reports

Amandine Valomon, Brady A Riedner, Stephanie G Jones, Keith P Nakamura, Giulio Tononi, David T Plante, Ruth M Benca, Melanie Boly

Affiliations

  1. Psychiatry - Wisconsin Institute for Sleep and Consciousness, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI, 53719, USA. [email protected].
  2. Psychiatry - Wisconsin Institute for Sleep and Consciousness, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI, 53719, USA.
  3. School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
  4. Neurology, University of Wisconsin-Madison, Madison, WI, USA.
  5. University of California Irvine, Psychiatry and Human Behavior, Irvine, CA, USA.

PMID: 33637812 PMCID: PMC7910582 DOI: 10.1038/s41598-021-83980-w

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by disrupting motor enactments during REM sleep, but also cognitive impairments across several domains. In addition to REM sleep abnormalities, we hypothesized that RBD patients may also display EEG abnormalities during NREM sleep. We collected all-night recordings with 256-channel high-density EEG in nine RBD patients, predominantly early-onset medicated individuals, nine sex- and age- matched healthy controls, and nine additional controls with matched medications and comorbidities. Power spectra in delta to gamma frequency bands were compared during both REM and NREM sleep, between phasic and tonic REM sleep, and between the first versus last cycle of NREM sleep. Controls, but not RBD patients, displayed a decrease in beta power during phasic compared to tonic REM sleep. Compared to controls, RBD patients displayed a reduced decline in SWA from early to late NREM sleep. Overnight changes in the distribution of the amplitude of slow waves were also reduced in RBD patients. Without suppression of beta rhythms during phasic REM sleep, RBD patients might demonstrate heightened cortical arousal, favoring the emergence of behavioral episodes. A blunted difference between REM sleep sub-stages may constitute a sensitive biomarker for RBD. Moreover, reduced overnight decline in SWA suggests a reduced capacity for synaptic plasticity in RBD patients, which may favor progression towards neurodegenerative diseases.

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