Display options
Cite
Tchivileva IE, Ohrbach R, Fillingim RB, et al. Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial. Cephalalgia. 2021;41(7):839-850doi: 10.1177/0333102421989268.
Tchivileva, I. E., Ohrbach, R., Fillingim, R. B., Lim, P. F., Giosia, M. D., Ribeiro-Dasilva, M., Campbell, J. H., Hadgraft, H., Willis, J., Arbes, S. J., & Slade, G. D. (2021). Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial. Cephalalgia : an international journal of headache, 41(7), 839-850. https://doi.org/10.1177/0333102421989268
Tchivileva, Inna E, et al. "Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial." Cephalalgia : an international journal of headache vol. 41,7 (2021): 839-850. doi: https://doi.org/10.1177/0333102421989268
Tchivileva IE, Ohrbach R, Fillingim RB, Lim PF, Giosia MD, Ribeiro-Dasilva M, Campbell JH, Hadgraft H, Willis J, Arbes SJ, Slade GD. Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial. Cephalalgia. 2021 Jun;41(7):839-850. doi: 10.1177/0333102421989268. Epub 2021 Feb 09. PMID: 33560875; PMCID: PMC8166404.
Copy Download .nbib Format: NLM
Share it on

Cephalalgia. 2021 Jun;41(7):839-850. doi: 10.1177/0333102421989268. Epub 2021 Feb 09.

Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial.

Cephalalgia : an international journal of headache

Inna E Tchivileva, Richard Ohrbach, Roger B Fillingim, Pei Feng Lim, Massimiliano Di Giosia, Margarete Ribeiro-Dasilva, John H Campbell, Holly Hadgraft, Janet Willis, Samuel J Arbes, Gary D Slade

Affiliations

  1. Center for Pain Research and Innovation, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  2. Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  3. Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
  4. Department of Community Dentistry and Behavioral Science, College of Dentistry, 3463University of Florida, Gainesville, FL, USA.
  5. Division of Diagnostic Sciences, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  6. Department of Restorative Dental Science, Prosthodontics Division, College of Dentistry, 3463University of Florida, Gainesville, FL, USA.
  7. Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
  8. 6015Rho Inc, Durham, NC, USA.
  9. Division of Pediatric and Public Health, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 33560875 PMCID: PMC8166404 DOI: 10.1177/0333102421989268

Abstract

INTRODUCTION: The migraine-preventive drug propranolol is efficacious in reducing pain from temporomandibular disorder, suggesting potential modifying or mediating effects of comorbid migraine.

METHODS: In this randomized controlled trial, myofascial temporomandibular disorder patients were treated with propranolol or placebo for 9 weeks. The primary endpoint was change in a facial pain index derived from daily symptom diaries. Linear and logistic regression models tested for a migraine × treatment-group interaction in reducing facial pain index. Counterfactual models explored changes in headache impact and heart rate as mediators of propranolol's efficacy.

RESULTS: Propranolol's efficacy in reducing facial pain index was greater among the 104 migraineurs than the 95 non-migraineurs: For example, for the binary ≥ 30% reduction in facial pain index, odds ratios were 3.3 (95% confidence limits: 1.4, 8.1) versus 1.3 (0.5, 3.2), respectively, although the interaction was statistically non-significant (

CONCLUSIONS: Propranolol was more efficacious in reducing temporomandibular disorder pain among migraineurs than non-migraineurs, with more of the effect mediated by reduced heart rate than by reduced headache impact.

STUDY IDENTIFICATION AND REGISTRATION: SOPPRANO; NCT02437383; https://clinicaltrials.gov/ct2/show/NCT02437383.

Keywords: Adrenergic beta-antagonists; autonomic nervous system; chronic pain; facial pain; headache; sympathetic nervous system

References

  1. Scand J Pain. 2018 Jul 26;18(3):479-489 - PubMed
  2. Neurosci Biobehav Rev. 2004 Jul;28(4):395-414 - PubMed
  3. Qual Life Res. 2003 Dec;12(8):963-74 - PubMed
  4. Acta Psychiatr Scand. 1983 Jun;67(6):361-70 - PubMed
  5. Physiotherapy. 2015 Sep;101(3):243-51 - PubMed
  6. Brain. 2005 Jan;128(Pt 1):86-97 - PubMed
  7. Cephalalgia. 2017 Jun;37(7):603 - PubMed
  8. Cephalalgia. 2014 Jan;34(1):29-36 - PubMed
  9. Epidemiology. 1992 Mar;3(2):143-55 - PubMed
  10. Nat Med. 2010 Nov;16(11):1284-93 - PubMed
  11. Pain. 2017 Oct;158(10):2025-2034 - PubMed
  12. Headache. 2012 Jun;52(6):946-56 - PubMed
  13. J Oral Facial Pain Headache. 2014 Winter;28(1):6-27 - PubMed
  14. Pain. 2020 Aug;161(8):1755-1767 - PubMed
  15. Pain. 1992 Aug;50(2):133-149 - PubMed
  16. J Am Dent Assoc. 2006 Sep;137(9):1267-74 - PubMed
  17. BMC Med Res Methodol. 2011 Jan 31;11:14 - PubMed
  18. Semin Arthritis Rheum. 2008 Jun;37(6):339-52 - PubMed
  19. J Oral Facial Pain Headache. 2016 Winter;30(1):7-13 - PubMed
  20. J Oral Facial Pain Headache. 2019 Jun 24;33(4):399–407 - PubMed
  21. J Oral Rehabil. 2016 Sep;43(9):702-15 - PubMed
  22. Hypertension. 2014 Dec;64(6):1334-43 - PubMed
  23. J Pain. 2011 Nov;12(11 Suppl):T75-91 - PubMed
  24. Pain. 2017 Jan;158(1):120-129 - PubMed
  25. Curr Pain Headache Rep. 2018 Feb 23;22(3):19 - PubMed
  26. Anesthesiology. 2016 May;124(5):1122-35 - PubMed
  27. Oral Maxillofac Surg Clin North Am. 2016 Aug;28(3):335-49 - PubMed
  28. J Neurophysiol. 1999 Mar;81(3):1104-12 - PubMed
  29. Neurosci Lett. 2012 Aug 30;524(2):129-32 - PubMed
  30. J Orofac Pain. 2010 Summer;24(3):287-92 - PubMed
  31. Pain. 2009 Dec;146(3):238-244 - PubMed
  32. Ann Otol Rhinol Laryngol. 1997 Oct;106(10 Pt 1):805-19 - PubMed
  33. BMJ. 2010 Mar 30;340:c117 - PubMed
  34. Cephalalgia. 2013 Jul;33(9):629-808 - PubMed

Publication Types

Grant support