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Molade JK, Onifade AA, Jimoh MA, et al. ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS. Ann Ib Postgrad Med. 2020;18(1):31-36
Molade, J. K., Onifade, A. A., Jimoh, M. A., Oyero, O. G., Ahube, I. C., Olawuyi, O. K., & Ayodeji, I. (2020). ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS. Annals of Ibadan postgraduate medicine, 18(1), 31-36.
Molade, J K, et al. "ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS." Annals of Ibadan postgraduate medicine vol. 18,1 (2020): 31-36.
Molade JK, Onifade AA, Jimoh MA, Oyero OG, Ahube IC, Olawuyi OK, Ayodeji I. ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS. Ann Ib Postgrad Med. 2020 Jun;18(1):31-36. PMID: 33623491; PMCID: PMC7893293.
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Ann Ib Postgrad Med. 2020 Jun;18(1):31-36.

ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS.

Annals of Ibadan postgraduate medicine

J K Molade, A A Onifade, M A Jimoh, O G Oyero, I C Ahube, O K Olawuyi, I Ayodeji

Affiliations

  1. Department of Chemical Pathology, College of Medicine, University of Ibadan.
  2. Department of Radiation Oncology, College of Medicine. University of Ibadan.
  3. Insititute of Advanced Medical Research and Training, College of Medicine, University of Ibadan.

PMID: 33623491 PMCID: PMC7893293

Abstract

BACKGROUND: Changes in immunological response have been reported during HBV infections, and these changes can be markers for the diagnosis and prediction of the outcome of infection The aim of this study was to measure and correlate serum levels of interleukin-2 (IL-2), C-reactive protein (CRP) Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and HBV antigens and antibodies in a sample of patients with HBV infection and in healthy controls.

METHODOS: The study population consisted of 26 patients with hepatitis B infection (HBsAg seropositive), and 26 apparently healthy (HBsAg seronegative) participants as controls. Biochemical markers of liver disease were evaluated by routine methods. Hepatitis B antigens (HBVsAg, HBeAg) and antibodies (HBsAb, HBeAb, HBcAb) were determined using immunochromatographic method. Serum concentrations of IL-2, and CRP were determined using ELISA method.

RESULTS: IL-2 level in HBsAg seropositive patients was found to be lower than that of control with no statistical significance while CRP level in HBV positive patients was higher than that of control with no statistical significance. HBV patients showed statistically significant difference in AST and ALT levels, compared to healthy controls. A statistically significant value was also observed between IL-2 and CRP in HBV infected individuals.

CONCLUSION: The study concluded that deranged ALT and AST values correlate with HBV infection and may be a potential tool for disease diagnosis and progression.

© Association of Resident Doctors, UCH, Ibadan.

Keywords: Alanine transferase; Aspartate transaminase; Hepatitis B antibodies; Hepatitis B antigens; IL-2, C-reactive protein

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