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Volovat SR, Volovat C, Miron I, et al. Oncogenic mechanisms in renal insufficiency. Clin Kidney J. 2020;14(2):507-515doi: 10.1093/ckj/sfaa122.
Volovat, S. R., Volovat, C., Miron, I., Kanbay, M., Goldsmith, D., Lungulescu, C., Badarau, S. C., & Covic, A. (2021). Oncogenic mechanisms in renal insufficiency. Clinical kidney journal, 14(2), 507-515. https://doi.org/10.1093/ckj/sfaa122
Volovat, Simona Ruxandra, et al. "Oncogenic mechanisms in renal insufficiency." Clinical kidney journal vol. 14,2 (2021): 507-515. doi: https://doi.org/10.1093/ckj/sfaa122
Volovat SR, Volovat C, Miron I, Kanbay M, Goldsmith D, Lungulescu C, Badarau SC, Covic A. Oncogenic mechanisms in renal insufficiency. Clin Kidney J. 2020 Oct 23;14(2):507-515. doi: 10.1093/ckj/sfaa122. eCollection 2021 Feb. PMID: 33623673; PMCID: PMC7886561.
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Clin Kidney J. 2020 Oct 23;14(2):507-515. doi: 10.1093/ckj/sfaa122. eCollection 2021 Feb.

Oncogenic mechanisms in renal insufficiency.

Clinical kidney journal

Simona Ruxandra Volovat, Constantin Volovat, Ingrith Miron, Mehmet Kanbay, David Goldsmith, Cristian Lungulescu, Silvia Corina Badarau, Adrian Covic

Affiliations

  1. Department of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.
  2. Department of Nephrology, Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
  3. Department of Nephrology, St George's University Hospital, London, UK.
  4. Department of Medical Oncology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

PMID: 33623673 PMCID: PMC7886561 DOI: 10.1093/ckj/sfaa122

Abstract

The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.

© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.

Keywords: cancer; carcinogenesis; end-stage renal disease; malignancy; renal transplant

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