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Angelova A, Angelov B, Drechsler M, et al. Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes. Front Cell Dev Biol. 2021;9:617984doi: 10.3389/fcell.2021.617984.
Angelova, A., Angelov, B., Drechsler, M., Bizien, T., Gorshkova, Y. E., & Deng, Y. (2021). Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes. Frontiers in cell and developmental biology, 9617984. https://doi.org/10.3389/fcell.2021.617984
Angelova, Angelina, et al. "Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes." Frontiers in cell and developmental biology vol. 9 (2021): 617984. doi: https://doi.org/10.3389/fcell.2021.617984
Angelova A, Angelov B, Drechsler M, Bizien T, Gorshkova YE, Deng Y. Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes. Front Cell Dev Biol. 2021 Feb 11;9:617984. doi: 10.3389/fcell.2021.617984. eCollection 2021. PMID: 33644054; PMCID: PMC7905036.
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Front Cell Dev Biol. 2021 Feb 11;9:617984. doi: 10.3389/fcell.2021.617984. eCollection 2021.

Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes.

Frontiers in cell and developmental biology

Angelina Angelova, Borislav Angelov, Markus Drechsler, Thomas Bizien, Yulia E Gorshkova, Yuru Deng

Affiliations

  1. Institut Galien Paris-Saclay UMR8612, Université Paris-Saclay, CNRS, Châtenay-Malabry, France.
  2. Institute of Physics, ELI Beamlines, Academy of Sciences of the Czech Republic, Prague, Czech.
  3. Keylab "Electron and Optical Microscopy", Bavarian Polymer Institute, University of Bayreuth, Bayreuth, Germany.
  4. Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin, France.
  5. Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia.
  6. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.

PMID: 33644054 PMCID: PMC7905036 DOI: 10.3389/fcell.2021.617984

Abstract

Structural properties of plasmenyl-glycerophospholipids (plasmalogens) have been scarcely studied for plasmalogens with long polyunsaturated fatty acid (PUFA) chains, despite of their significance for the organization and functions of the cellular membranes. Elaboration of supramolecular assemblies involving PUFA-chain plasmalogens in nanostructured mixtures with lyotropic lipids may accelerate the development of nanomedicines for certain severe pathologies (e.g., peroxisomal disorders, cardiometabolic impairments, and neurodegenerative Alzheimer's and Parkinson's diseases). Here, we investigate the spontaneous self-assembly of bioinspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM). A coexistence of a liquid crystalline primitive cubic

Copyright © 2021 Angelova, Angelov, Drechsler, Bizien, Gorshkova and Deng.

Keywords: SAXS; cryo-TEM; docosapentaenoyl phospholipids; hexosomes; inverted hexagonal phase; lipid cubic phase; plasmalogen-loaded cubosomes

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declare

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