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Li WH, Seo I, Kim B, et al. Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro. Int J Cosmet Sci. 2021;43(3):311-320doi: 10.1111/ics.12698.
Li, W. H., Seo, I., Kim, B., Fassih, A., Southall, M. D., & Parsa, R. (2021). Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro. International journal of cosmetic science, 43(3), 311-320. https://doi.org/10.1111/ics.12698
Li, Wen-Hwa, et al. "Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro." International journal of cosmetic science vol. 43,3 (2021): 311-320. doi: https://doi.org/10.1111/ics.12698
Li WH, Seo I, Kim B, Fassih A, Southall MD, Parsa R. Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro. Int J Cosmet Sci. 2021 Jun;43(3):311-320. doi: 10.1111/ics.12698. Epub 2021 May 25. PMID: 33594706.
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Int J Cosmet Sci. 2021 Jun;43(3):311-320. doi: 10.1111/ics.12698. Epub 2021 May 25.

Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro.

International journal of cosmetic science

Wen-Hwa Li, InSeok Seo, Brian Kim, Ali Fassih, Michael D Southall, Ramine Parsa

Affiliations

  1. The Johnson & Johnson Skin Research Center, Johnson & Johnson Consumer Inc., Skillman, NJ, USA.

PMID: 33594706 DOI: 10.1111/ics.12698

Abstract

OBJECTIVE: Light therapy has attracted medical interests as a safe, alternative treatment for photo-ageing and photo-damaged skin. Recent research suggested the therapeutic activity of red and infrared (IR) lights may be effective at much lower energy levels than those used clinically. This study was to evaluate the efficacy of low-level red plus near IR light emitting diode (LED) combination on collagen and elastin and ATP production.

METHODS: Human dermal fibroblasts or skin tissues were irradiated daily by red (640 nm) plus near IR (830 nm) LED lights combination at 0.5 mW/cm

RESULTS: Treatment of human fibroblast cell cultures with low-level red plus near IR lights combination was found to significantly increase LOXL1, ELN and COL1A1 and COL3A1 gene expressions as well as the synthesis of the procollagen type I and elastin proteins. Treating human skin explants with low-level red plus near IR lights combination similarly induced significant increases in the same gene expressions, type III collagen and elastic fibre formation and crosslinks. ATP production was increased in human dermal fibroblasts after red plus near IR lights combination treatment.

CONCLUSION: Low-level red plus near IR lights combination stimulated the production of collagen and elastin production associated with anti-ageing benefits. These findings suggest that low-level red plus near IR LED light combination may provide an effective treatment opportunity for people with photo-aged skin.

© 2021 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Keywords: genomic/proteomic/ELISA/cell culture; photo-biomodulation; skin physiology/structure

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