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Khan H, Singh A, Thapa K, et al. Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res. 2021;147399doi: 10.1016/j.brainres.2021.147399.
Khan, H., Singh, A., Thapa, K., Garg, N., Grewal, A. K., & Singh, T. G. (2021). Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain research, 147399. https://doi.org/10.1016/j.brainres.2021.147399
Khan, Heena, et al. "Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury." Brain research vol. (2021): 147399. doi: https://doi.org/10.1016/j.brainres.2021.147399
Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG. Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res. 2021 Mar 02;147399. doi: 10.1016/j.brainres.2021.147399. Epub 2021 Mar 02. PMID: 33662337.
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Brain Res. 2021 Mar 02;147399. doi: 10.1016/j.brainres.2021.147399. Epub 2021 Mar 02.

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury.

Brain research

Heena Khan, Anjali Singh, Komal Thapa, Nikhil Garg, Amarjot Kaur Grewal, Thakur Gurjeet Singh

Affiliations

  1. Chitkara College of Pharmacy, Chitkara University, Punjab, India.
  2. Chitkara College of Pharmacy, Chitkara University, Punjab, India; School of Pharmacy, Chitkara University, Himachal Pradesh, India.
  3. Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address: [email protected].

PMID: 33662337 DOI: 10.1016/j.brainres.2021.147399

Abstract

The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients. phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in association with its downstream targets, other receptors, and pathways that may offer antioxidant, anti-inflammatory, anti-apoptotic effects, neuroprotective role in neuronal excitotoxicity. This review elaborates the mechanistic interventions of the PI3K pathway in cerebral ischemic injury in context to nuclear factor erythroid 2-related factor 2 (Nrf2) regulation, Hypoxia-inducible factor 1 signaling (HIF-1), growth factors, Endothelial NOS (eNOS) proinflammatory cytokines, Erythropoietin (EPO), Phosphatase and tensin homologous protein of chromosome 10 gene (PTEN) signaling, NF-κB/Notch signaling, c-Jun N-terminal kinase (JNK) and Glycogen synthase kinase-3β (GSK-3β) signaling pathway. Evidences showing the activation of PI3K inhibits apoptotic pathway, which results in its neuroprotective effect in ischemic injury. Despite discussing the therapeutic role of the PI3K pathway in treating cerebral ischemic injury, the review also enlighten the selective modulation of PI3K pathway with activators and inhibitors which may provide promising results in clinical and preclinical settings.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: JNK pathway; Neural apoptosis; Nrf2; PI3K inhibitors; PI3K signaling pathway; Stroke

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