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Wong MK, Barbulescu P, Coburn B, et al. Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses. Microbes Infect. 2021;23(6):104804doi: 10.1016/j.micinf.2021.104804.
Wong, M. K., Barbulescu, P., Coburn, B., & Reguera-Nuñez, E. (2021). Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses. Microbes and infection, 23(6), 104804. https://doi.org/10.1016/j.micinf.2021.104804
Wong, Matthew K, et al. "Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses." Microbes and infection vol. 23,6 (2021): 104804. doi: https://doi.org/10.1016/j.micinf.2021.104804
Wong MK, Barbulescu P, Coburn B, Reguera-Nuñez E. Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses. Microbes Infect. 2021 Jul-Aug;23(6):104804. doi: 10.1016/j.micinf.2021.104804. Epub 2021 Feb 27. PMID: 33652120.
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Microbes Infect. 2021 Jul-Aug;23(6):104804. doi: 10.1016/j.micinf.2021.104804. Epub 2021 Feb 27.

Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses.

Microbes and infection

Matthew K Wong, Philip Barbulescu, Bryan Coburn, Elaine Reguera-Nuñez

Affiliations

  1. Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
  2. Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Department of Medicine, Division of Infectious Diseases, University Health Network, Toronto, M5G 0A3, Canada. Electronic address: [email protected].
  3. Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, M5G 0A3, Canada. Electronic address: [email protected].

PMID: 33652120 DOI: 10.1016/j.micinf.2021.104804

Abstract

The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Keywords: Bacterial consortia; Bacterial metabolites; Gut microbiota; Immune checkpoint inhibitor; Immune modulation

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