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Sonesson A, Malm J, Rylander L, et al. Serum amyloid P component: a new biomarker for low sperm concentration?. Asian J Androl. 2021;23(5):450-455doi: 10.4103/aja.aja_7_21.
Sonesson, A., Malm, J., Rylander, L., Giwercman, A., & Hillarp, A. (2021). Serum amyloid P component: a new biomarker for low sperm concentration?. Asian journal of andrology, 23(5), 450-455. https://doi.org/10.4103/aja.aja_7_21
Sonesson, Annika, et al. "Serum amyloid P component: a new biomarker for low sperm concentration?." Asian journal of andrology vol. 23,5 (2021): 450-455. doi: https://doi.org/10.4103/aja.aja_7_21
Sonesson A, Malm J, Rylander L, Giwercman A, Hillarp A. Serum amyloid P component: a new biomarker for low sperm concentration?. Asian J Androl. 2021 Sep-Oct;23(5):450-455. doi: 10.4103/aja.aja_7_21. PMID: 33723096; PMCID: PMC8451485.
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Asian J Androl. 2021 Sep-Oct;23(5):450-455. doi: 10.4103/aja.aja_7_21.

Serum amyloid P component: a new biomarker for low sperm concentration?.

Asian journal of andrology

Annika Sonesson, Johan Malm, Lars Rylander, Aleksander Giwercman, Andreas Hillarp

Affiliations

  1. Department of Translational Medicine, Lund University, Malmö 20502, Sweden.
  2. University and Regional Laboratories Region Skåne, Department of Clinical Chemistry and Pharmacology, Malmö 20502, Sweden.
  3. Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund 22381, Sweden.

PMID: 33723096 PMCID: PMC8451485 DOI: 10.4103/aja.aja_7_21

Abstract

Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r = -0.19), progressive sperm motility (r = 0.24), and sperm immotility (r = -0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration < or ≥5 × 10

Keywords: fertility; reproduction; seminal plasma; serum amyloid P component; sperm

Conflict of interest statement

None

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