Display options
Cite
Cosma S, Carosso AR, Borella F, et al. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics (Basel). 2021;11(3)doi: 10.3390/diagnostics11030398.
Cosma, S., Carosso, A. R., Borella, F., Cusato, J., Bovetti, M., Bevilacqua, F., Carosso, M., Gervasoni, F., Sciarrone, A., Marozio, L., Revelli, A., Rolfo, A., Filippini, C., Ghisetti, V., Di Perri, G., & Benedetto, C. (2021). Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics (Basel, Switzerland), 11(3), . https://doi.org/10.3390/diagnostics11030398
Cosma, Stefano, et al. "Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study." Diagnostics (Basel, Switzerland) vol. 11,3 (2021). doi: https://doi.org/10.3390/diagnostics11030398
Cosma S, Carosso AR, Borella F, Cusato J, Bovetti M, Bevilacqua F, Carosso M, Gervasoni F, Sciarrone A, Marozio L, Revelli A, Rolfo A, Filippini C, Ghisetti V, Di Perri G, Benedetto C. Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study. Diagnostics (Basel). 2021 Feb 26;11(3). doi: 10.3390/diagnostics11030398. PMID: 33652805; PMCID: PMC7996827.
Copy Download .nbib Format: NLM
Share it on

Diagnostics (Basel). 2021 Feb 26;11(3). doi: 10.3390/diagnostics11030398.

Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study.

Diagnostics (Basel, Switzerland)

Stefano Cosma, Andrea Roberto Carosso, Fulvio Borella, Jessica Cusato, Marialuisa Bovetti, Federica Bevilacqua, Marco Carosso, Fiammetta Gervasoni, Andrea Sciarrone, Luca Marozio, Alberto Revelli, Alessandro Rolfo, Claudia Filippini, Valeria Ghisetti, Giovanni Di Perri, Chiara Benedetto

Affiliations

  1. Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy.
  2. Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
  3. Obstetrics-Gynecological Ultrasound and Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, City of Health and Science, 10126 Turin, Italy.
  4. Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy.
  5. Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL 'Città di Torino', 10126 Turin, Italy.
  6. Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

PMID: 33652805 PMCID: PMC7996827 DOI: 10.3390/diagnostics11030398

Abstract

This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (

Keywords: COVID-19; SARS-CoV-2; fetal congenital anomalies; fetus; first trimester; nuchal translucency; prenatal screening test; vertical transmission

References

  1. J Clin Microbiol. 2020 May 26;58(6): - PubMed
  2. Lancet. 2020 Aug 22;396(10250):530-531 - PubMed
  3. Birth Defects Res. 2017 Mar 15;109(5):353-362 - PubMed
  4. Eur J Clin Microbiol Infect Dis. 2008 Sep;27(9):863-6 - PubMed
  5. Ultrasound Obstet Gynecol. 2021 Feb;57(2):242-247 - PubMed
  6. J Med Virol. 2021 Jan;93(1):537-540 - PubMed
  7. Ultrasound Obstet Gynecol. 2021 Feb;57(2):232-241 - PubMed
  8. Am J Obstet Gynecol. 2020 May;222(5):415-426 - PubMed
  9. Nat Med. 2020 Jul;26(7):1037-1040 - PubMed
  10. Eur J Obstet Gynecol Reprod Biol. 2020 Jun;249:98-99 - PubMed
  11. Lancet. 2014 Sep 6;384(9946):869-79 - PubMed
  12. Arch Pathol Lab Med. 2017 Jan;141(1):26-32 - PubMed
  13. N Engl J Med. 1999 Aug 12;341(7):461-7 - PubMed
  14. Virol Sin. 2020 Jun;35(3):290-304 - PubMed
  15. Open Biol. 2020 Aug;10(8):200162 - PubMed
  16. Trans R Soc Trop Med Hyg. 2000 Jan-Feb;94(1):1-2 - PubMed
  17. Am J Obstet Gynecol. 2021 Apr;224(4):391.e1-391.e7 - PubMed
  18. Clin Microbiol Infect. 2020 Dec;26(12):1690.e1-1690.e4 - PubMed
  19. Ultrasound Obstet Gynecol. 2020 Jun;55(6):863-870 - PubMed
  20. Hum Reprod. 2021 Jan 1;36(1):40-47 - PubMed
  21. Nat Rev Immunol. 2020 Jun;20(6):339-341 - PubMed
  22. Am J Obstet Gynecol. 2021 Jan;224(1):35-53.e3 - PubMed
  23. Clin Transl Immunology. 2020 Sep 26;9(9):e1182 - PubMed
  24. Nature. 2018 Nov;563(7731):337-338 - PubMed
  25. Am J Obstet Gynecol. 2020 Oct;223(4):612 - PubMed
  26. J Am Heart Assoc. 2019 May 7;8(9):e011264 - PubMed
  27. Case Rep Obstet Gynecol. 2019 Jul 7;2019:3259760 - PubMed
  28. PLoS One. 2020 Dec 10;15(12):e0238409 - PubMed
  29. Elife. 2020 Jul 14;9: - PubMed
  30. Eur J Obstet Gynecol Reprod Biol. 2020 Jul;250:246-249 - PubMed

Publication Types

Grant support