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Schmoyer CJ, Saidman J, Bohl JL, et al. The Pathogenesis and Clinical Management of Stricturing Crohn Disease. Inflamm Bowel Dis. 2021;27(11):1839-1852doi: 10.1093/ibd/izab038.
Schmoyer, C. J., Saidman, J., Bohl, J. L., Bierly, C. L., Kuemmerle, J. F., & Bickston, S. J. (2021). The Pathogenesis and Clinical Management of Stricturing Crohn Disease. Inflammatory bowel diseases, 27(11), 1839-1852. https://doi.org/10.1093/ibd/izab038
Schmoyer, Christopher J, et al. "The Pathogenesis and Clinical Management of Stricturing Crohn Disease." Inflammatory bowel diseases vol. 27,11 (2021): 1839-1852. doi: https://doi.org/10.1093/ibd/izab038
Schmoyer CJ, Saidman J, Bohl JL, Bierly CL, Kuemmerle JF, Bickston SJ. The Pathogenesis and Clinical Management of Stricturing Crohn Disease. Inflamm Bowel Dis. 2021 Oct 20;27(11):1839-1852. doi: 10.1093/ibd/izab038. PMID: 33693860.
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Inflamm Bowel Dis. 2021 Oct 20;27(11):1839-1852. doi: 10.1093/ibd/izab038.

The Pathogenesis and Clinical Management of Stricturing Crohn Disease.

Inflammatory bowel diseases

Christopher J Schmoyer, Jakob Saidman, Jaime L Bohl, Claire L Bierly, John F Kuemmerle, Stephen J Bickston

Affiliations

  1. Virginia Commonwealth University, Division of Gastroenterology and Hepatology, Richmond, Virginia, USA.
  2. Virginia Commonwealth University, Division of Colorectal Surgery, Richmond, Virginia, USA.
  3. Virginia Commonwealth University, Department of Physiology and Biophysics, Richmond, Virginia, USA.

PMID: 33693860 DOI: 10.1093/ibd/izab038

Abstract

Stricturing of the gastrointestinal tract is a common complication in Crohn disease and is a significant cause of morbidity and mortality among this population. The inflammatory process initiates fibrosis, leading to aberrant wound healing and excess deposition of extracellular matrix proteins. Our understanding of this process has grown and encompasses cellular mechanisms, epigenetic modifications, and inherent genetic predisposition toward fibrosis. Although medications can improve inflammation, there is still no drug to attenuate scar formation. As such, management of stricturing disease requires a multidisciplinary and individualized approach including medical management, therapeutic endoscopy, and surgery. This review details the current understanding regarding the pathogenesis, detection, and management of stricturing Crohn disease.

© 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Crohn; Montreal B2; biologic therapy; endoscopy; fibrosis; medical therapy; pathogenesis; stricture; surgery; treatment

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