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Yuksel MK, Remien CH, Karki B, et al. Vector dynamics influence spatially imperfect genetic interventions against disease. Evol Med Public Health. 2020;9(1):1-10doi: 10.1093/emph/eoaa035.
Yuksel, M. K., Remien, C. H., Karki, B., Bull, J. J., & Krone, S. M. (2021). Vector dynamics influence spatially imperfect genetic interventions against disease. Evolution, medicine, and public health, 9(1), 1-10. https://doi.org/10.1093/emph/eoaa035
Yuksel, Mete K, et al. "Vector dynamics influence spatially imperfect genetic interventions against disease." Evolution, medicine, and public health vol. 9,1 (2021): 1-10. doi: https://doi.org/10.1093/emph/eoaa035
Yuksel MK, Remien CH, Karki B, Bull JJ, Krone SM. Vector dynamics influence spatially imperfect genetic interventions against disease. Evol Med Public Health. 2020 Dec 27;9(1):1-10. doi: 10.1093/emph/eoaa035. eCollection 2021. PMID: 33664955; PMCID: PMC7910803.
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Evol Med Public Health. 2020 Dec 27;9(1):1-10. doi: 10.1093/emph/eoaa035. eCollection 2021.

Vector dynamics influence spatially imperfect genetic interventions against disease.

Evolution, medicine, and public health

Mete K Yuksel, Christopher H Remien, Bandita Karki, James J Bull, Stephen M Krone

Affiliations

  1. Department of Mathematics, University of Idaho, Moscow, ID 83844-1103, USA.
  2. Department of Biological Sciences, University of Idaho, Moscow, ID 83844-1103, USA.

PMID: 33664955 PMCID: PMC7910803 DOI: 10.1093/emph/eoaa035

Abstract

BACKGROUND AND OBJECTIVES: Genetic engineering and similar technologies offer promising new approaches to controlling human diseases by blocking transmission from vectors. However, in spatially structured populations, imperfect coverage of the vector will leave pockets in which the parasite may persist. Movement by humans may disrupt this local persistence and facilitate eradication when these pockets are small, spreading parasite reproduction outside unprotected areas and into areas that block its reproduction. Here, we consider the sensitivity of this process to biological details: do simple generalities emerge that may facilitate interventions?

METHODOLOGY: We develop formal mathematical models of this process similar to standard Ross-Macdonald models, but (i) specifying spatial structure of two patches, with vector transmission blocked in one patch but not in the other, (ii) allowing temporary human movement (travel instead of migration) and (iii) considering two different modes of mosquito biting.

RESULTS: We find that there is no invariant effect of disrupting spatial structure with travel. For both biting models, travel out of the unprotected patch has different consequences than travel by visitors into the patch, but the effects are reversed between the two biting models.

CONCLUSIONS AND IMPLICATIONS: Overall, the effect of human travel on the maintenance of vector-borne diseases in structured habitats must be considered in light of the actual biology of mosquito abundances, biting dynamics and human movement patterns.

© The Author(s) 2020. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.

Keywords: gene drive; genetic pest management; mathematical model; mosquito biting dynamics; pathogen suppression; spatial structure

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