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Kasza I, Kühn JP, Völzke H, et al. Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human. J Physiol. 2021;doi: 10.1113/JP280922.
Kasza, I., Kühn, J. P., Völzke, H., Hernando, D., Xu, Y. G., Siebert, J. W., Gibson, A. L., Yen, C. E., Nelson, D. W., MacDougald, O. A., Richardson, N. E., Lamming, D. W., Kern, P. A., & Alexander, C. M. (2021). Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human. The Journal of physiology, . https://doi.org/10.1113/JP280922
Kasza, Ildiko, et al. "Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human." The Journal of physiology vol. (2021). doi: https://doi.org/10.1113/JP280922
Kasza I, Kühn JP, Völzke H, Hernando D, Xu YG, Siebert JW, Gibson AL, Yen CE, Nelson DW, MacDougald OA, Richardson NE, Lamming DW, Kern PA, Alexander CM. Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human. J Physiol. 2021 Mar 16; doi: 10.1113/JP280922. Epub 2021 Mar 16. PMID: 33724479; PMCID: PMC8443702.
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J Physiol. 2021 Mar 16; doi: 10.1113/JP280922. Epub 2021 Mar 16.

Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human.

The Journal of physiology

Ildiko Kasza, Jens-Peter Kühn, Henry Völzke, Diego Hernando, Yaohui G Xu, John W Siebert, Angela Lf Gibson, C-L Eric Yen, David W Nelson, Ormond A MacDougald, Nicole E Richardson, Dudley W Lamming, Philip A Kern, C M Alexander

Affiliations

  1. McArdle Laboratory for Cancer Research, University of Wisconsin-Madison.
  2. Institute and Policlinic of Diagnostic and Interventional Radiology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany.
  3. Institute of Community Medicine, University of Greifswald, Germany.
  4. Departments of Radiology, University of Wisconsin-School of Medicine and Public Health.
  5. Medical Physics, University of Wisconsin-School of Medicine and Public Health.
  6. Dermatology, University of Wisconsin-School of Medicine and Public Health.
  7. Surgery, University of Wisconsin-School of Medicine and Public Health.
  8. Department of Nutritional Sciences, University of Wisconsin-Madison.
  9. Department of Molecular & Integrative Physiology, University of Michigan.
  10. Medicine, University of Wisconsin-School of Medicine and Public Health.
  11. William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
  12. Department of Internal Medicine, University of Kentucky, Lexington.

PMID: 33724479 PMCID: PMC8443702 DOI: 10.1113/JP280922

Abstract

KEY POINTS: Several distinct strategies produce and conserve heat to maintain body temperature of mammals, each associated with unique physiologies, with consequence for wellness and disease susceptibility Highly regulated properties of skin offset the total requirement for heat production  We hypothesize that the adipose component of skin is primarily responsible for modulating heat flux; here we evaluate the relative regulation of adipose depots in mouse and human, to test their recruitment to heat production and conservation We found that insulating mouse dermal white adipose tissue accumulates in response to environmentally- and genetically-induced cool stress; this layer is one of two adipose depots closely apposed to mouse skin, where the subcutaneous mammary gland fat pads are actively recruited to heat production In contrast, the body-wide adipose depot associated with human skin produces heat directly, potentially creating an alternative to the centrally regulated brown adipose tissue ABSTRACT: Mammalian skin impacts metabolic efficiency system-wide, controlling the rate of heat loss and consequent heat production. Here we compare the unique fat depots associated with mouse and human skin, to determine whether they have corresponding function and regulation. For human, we assay a skin-associated fat (SAF) body-wide depot to distinguish it from the subcutaneous fat pads characteristic of abdomen and upper limbs. We show that the thickness of SAF is not related to general adiposity; it is much thicker (1.6-fold) in women than men, and highly subject-specific. We used molecular and cellular assays of β-adrenergic induced lipolysis and found that dermal white adipose tissue (dWAT) in mice is resistant to lipolysis; in contrast, the body-wide human SAF depot becomes lipolytic, generating heat in response to β-adrenergic stimulation. In mice challenged to make more heat to maintain body temperature (either environmentally or genetically), there is a compensatory increase in thickness of dWAT: A corresponding β-adrenergic stimulation of human skin adipose (in vivo or in explant) depletes adipocyte lipid content. We summarize the regulation of skin-associated adipocytes by age, sex, and adiposity, for both species. We conclude that the body-wide dWAT depot of mice shows unique regulation that enables it to be deployed for heat preservation; combined with the actively lipolytic subcutaneous mammary fat pads they enable thermal defense. The adipose tissue that covers human subjects produces heat directly, providing an alternative to the brown adipose tissues. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Keywords: BAT brown adipose tissue; Dermal white adipose tissue; MRI magnetic resonance imaging; SAF skin-associated fat; UCP1; brown adipose tissue; dWAT; dWAT dermal white adipose tissue; heat production; iWAT inguinal (mouse subcutaneous) white adipose tissue; lipolysis; obesity; scWAT; scWAT subcutaneous white adipose tissue; skin-associated fat; subcutaneous white adipose tissue; thermogenesis; vWAT visceral white adipose tissue; β-adrenergic response

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