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Lakshmanan LN, Yee Z, Halliwell B, et al. Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints. iScience. 2021;24(3):102138doi: 10.1016/j.isci.2021.102138.
Lakshmanan, L. N., Yee, Z., Halliwell, B., Gruber, J., & Gunawan, R. (2021). Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints. iScience, 24(3), 102138. https://doi.org/10.1016/j.isci.2021.102138
Lakshmanan, Lakshmi Narayanan, et al. "Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints." iScience vol. 24,3 (2021): 102138. doi: https://doi.org/10.1016/j.isci.2021.102138
Lakshmanan LN, Yee Z, Halliwell B, Gruber J, Gunawan R. Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints. iScience. 2021 Feb 04;24(3):102138. doi: 10.1016/j.isci.2021.102138. eCollection 2021 Mar 19. PMID: 33665557; PMCID: PMC7900216.
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iScience. 2021 Feb 04;24(3):102138. doi: 10.1016/j.isci.2021.102138. eCollection 2021 Mar 19.

Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints.

iScience

Lakshmi Narayanan Lakshmanan, Zhuangli Yee, Barry Halliwell, Jan Gruber, Rudiyanto Gunawan

Affiliations

  1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  2. Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.
  3. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
  4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  5. Ageing Research Laboratory, Science Division, Yale-NUS College, Singapore, Singapore.
  6. Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, NY, USA.

PMID: 33665557 PMCID: PMC7900216 DOI: 10.1016/j.isci.2021.102138

Abstract

Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion mutations, details such as the specific DNA repair errors are still lacking. Here, we used DNA hybridization thermodynamics to infer the sequence lengths of mtDNA misalignments that are associated with mtDNA deletions. We gathered and analyzed 9,921 previously reported mtDNA deletion breakpoints in human, rhesus monkey, mouse, rat, and

© 2021 The Author(s).

Keywords: Bioinformatics; Molecular Genetics; Sequence Analysis

Conflict of interest statement

The authors declare no competing interests.

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