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van de Vyver M, Powrie YSL, Smith C. Targeting Stem Cells in Chronic Inflammatory Diseases. Adv Exp Med Biol. 2021;1286:163-181doi: 10.1007/978-3-030-55035-6_12.
van de Vyver, M., Powrie, Y. S. L., & Smith, C. (2021). Targeting Stem Cells in Chronic Inflammatory Diseases. Advances in experimental medicine and biology, 1286163-181. https://doi.org/10.1007/978-3-030-55035-6_12
van de Vyver, Mari, et al. "Targeting Stem Cells in Chronic Inflammatory Diseases." Advances in experimental medicine and biology vol. 1286 (2021): 163-181. doi: https://doi.org/10.1007/978-3-030-55035-6_12
van de Vyver M, Powrie YSL, Smith C. Targeting Stem Cells in Chronic Inflammatory Diseases. Adv Exp Med Biol. 2021;1286:163-181. doi: 10.1007/978-3-030-55035-6_12. PMID: 33725353.
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Adv Exp Med Biol. 2021;1286:163-181. doi: 10.1007/978-3-030-55035-6_12.

Targeting Stem Cells in Chronic Inflammatory Diseases.

Advances in experimental medicine and biology

Mari van de Vyver, Yigael S L Powrie, Carine Smith

Affiliations

  1. Department of Medicine, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa. [email protected].
  2. Department of Medicine, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa.
  3. Department of Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa.

PMID: 33725353 DOI: 10.1007/978-3-030-55035-6_12

Abstract

Mesenchymal stem cell (MSC) dysfunction is a serious complication in ageing and age-related inflammatory diseases such as type 2 diabetes mellitus. Inflammation and oxidative stress-induced cellular senescence alter the immunomodulatory ability of MSCs and hamper their pro-regenerative function, which in turn leads to an increase in disease severity, maladaptive tissue damage and the development of comorbidities. Targeting stem/progenitor cells to restore their function and/or protect them against impairment could thus improve healing outcomes and significantly enhance the quality of life for diabetic patients. This review discusses the dysregulation of MSCs' immunomodulatory capacity in the context of diabetes mellitus and focuses on intervention strategies aimed at MSC rejuvenation. Research pertaining to the potential therapeutic use of either pharmacological agents (NFкB antagonists), natural products (phytomedicine) or biological agents (exosomes, probiotics) to improve MSC function is discussed and an overview of the most pertinent methodological considerations given. Based on in vitro studies, numerous anti-inflammatory agents, antioxidants and biological agents show tremendous potential to revitalise MSCs. An integrated systems approach and a thorough understanding of complete disease pathology are however required to identify feasible candidates for in vivo targeting of MSCs.

Keywords: Accelerated ageing; Antioxidant; Exosome; Extracellular vesicles; Mesenchymal stem cells; Probiotic; Type 2 diabetes

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