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Meza U, Romero-Méndez C, Sánchez-Armáss S, et al. Participación de rafts en enfermedades neurológicas. Role of rafts in neurological disorders. Neurologia (Engl Ed). 2021;doi: 10.1016/j.nrl.2021.01.008.
Meza, U., Romero-Méndez, C., Sánchez-Armáss, S., & Rodríguez-Menchaca, A. A. (2021). Participación de rafts en enfermedades neurológicas. Role of rafts in neurological disorders. Neurologia (Barcelona, Spain), . https://doi.org/10.1016/j.nrl.2021.01.008
Meza, U, et al. "Participación de rafts en enfermedades neurológicas." Role of rafts in neurological disorders. Neurologia (Barcelona, Spain) vol. (2021). doi: https://doi.org/10.1016/j.nrl.2021.01.008
Meza U, Romero-Méndez C, Sánchez-Armáss S, Rodríguez-Menchaca AA. Participación de rafts en enfermedades neurológicas. Role of rafts in neurological disorders. Neurologia (Engl Ed). 2021 Mar 13; doi: 10.1016/j.nrl.2021.01.008. Epub 2021 Mar 13. Spanish. PMID: 33726969.
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Neurologia (Engl Ed). 2021 Mar 13; doi: 10.1016/j.nrl.2021.01.008. Epub 2021 Mar 13.

Role of rafts in neurological disorders.

Neurologia (Barcelona, Spain)

[Article in Spanish]
U Meza, C Romero-Méndez, S Sánchez-Armáss, A A Rodríguez-Menchaca

Affiliations

  1. Departamento de Fisiología y Biofísica. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address: [email protected].
  2. Departamento de Fisiología y Biofísica. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.

PMID: 33726969 DOI: 10.1016/j.nrl.2021.01.008

Abstract

INTRODUCTION: Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains.

DEVELOPMENT: In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases.

CONCLUSIONS: Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.

Copyright © 2021 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords: Alzheimer; Caveola; Caveolae; Cell membrane; Cholesterol; Colesterol; Huntington; Membrana celular; Parkinson

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