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Calvo C, Fenneteau O, Leverger G, et al. Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity. Cancers (Basel). 2021;13(4)doi: 10.3390/cancers13040777.
Calvo, C., Fenneteau, O., Leverger, G., Petit, A., Baruchel, A., & Méchinaud, F. (2021). Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity. Cancers, 13(4), . https://doi.org/10.3390/cancers13040777
Calvo, Charlotte, et al. "Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity." Cancers vol. 13,4 (2021). doi: https://doi.org/10.3390/cancers13040777
Calvo C, Fenneteau O, Leverger G, Petit A, Baruchel A, Méchinaud F. Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity. Cancers (Basel). 2021 Feb 13;13(4). doi: 10.3390/cancers13040777. PMID: 33668444; PMCID: PMC7918235.
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Cancers (Basel). 2021 Feb 13;13(4). doi: 10.3390/cancers13040777.

Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity.

Cancers

Charlotte Calvo, Odile Fenneteau, Guy Leverger, Arnaud Petit, André Baruchel, Françoise Méchinaud

Affiliations

  1. Pediatric Hematology and Immunology Department, Robert Debré University Hospital (APHP and Université de Paris), 75019 Paris, France.
  2. Hematopathology Department, Robert Debré University Hospital (APHP and Université de Paris), 75019 Paris, France.
  3. Pediatric Immunology, Hematology and Oncology Department, Trousseau Hospital (APHP and Université Paris Sorbonne), 75012 Paris, France.

PMID: 33668444 PMCID: PMC7918235 DOI: 10.3390/cancers13040777

Abstract

Infant acute myeloid leukemia (AML) is a rare subgroup of AML of children <2 years of age. It is as frequent as infant acute lymphoblastic leukemia (ALL) but not clearly distinguished by study groups. However, infant AML demonstrates peculiar clinical and biological characteristics, and its prognosis differs from AML in older children. Acute megakaryoblastic leukemia (AMKL) is very frequent in this age group and has raised growing interest. Thus, AMKL is a dominant topic in this review. Recent genomic sequencing has contributed to our understanding of infant AML. These data demonstrated striking features of infant AML: fusion genes are able to induce AML transformation without additional cooperation, and unlike AML in older age groups there is a paucity of associated mutations. Mice modeling of these fusions showed the essential role of ontogeny in the infant leukemia phenotype compared to older children and adults. Understanding leukemogenesis may help in developing new targeted treatments to improve outcomes that are often very poor in this age group. A specific diagnostic and therapeutic approach for this age group should be investigated.

Keywords: AML; acute myeloid leukemia; childhood; infant

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