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Yang W, Cong Y. Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases. Cell Mol Immunol. 2021;18(4):866-877doi: 10.1038/s41423-021-00661-4.
Yang, W., & Cong, Y. (2021). Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases. Cellular & molecular immunology, 18(4), 866-877. https://doi.org/10.1038/s41423-021-00661-4
Yang, Wenjing, and Cong, Yingzi. "Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases." Cellular & molecular immunology vol. 18,4 (2021): 866-877. doi: https://doi.org/10.1038/s41423-021-00661-4
Yang W, Cong Y. Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases. Cell Mol Immunol. 2021 Apr;18(4):866-877. doi: 10.1038/s41423-021-00661-4. Epub 2021 Mar 11. PMID: 33707689; PMCID: PMC8115644.
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Cell Mol Immunol. 2021 Apr;18(4):866-877. doi: 10.1038/s41423-021-00661-4. Epub 2021 Mar 11.

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases.

Cellular & molecular immunology

Wenjing Yang, Yingzi Cong

Affiliations

  1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. [email protected].
  3. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. [email protected].

PMID: 33707689 PMCID: PMC8115644 DOI: 10.1038/s41423-021-00661-4

Abstract

The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary components or by the host and can be modified by gut bacteria or synthesized de novo by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.

Keywords: B cells; T cells; autoimmune diseases; gut microbiota; metabolites

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