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Gibson CR, Gleason A, Messina E. Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging. Pharmacol Res Perspect. 2021;9(2):e00731doi: 10.1002/prp2.731.
Gibson, C. R., Gleason, A., & Messina, E. (2021). Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging. Pharmacology research & perspectives, 9(2), e00731. https://doi.org/10.1002/prp2.731
Gibson, Christopher R, et al. "Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging." Pharmacology research & perspectives vol. 9,2 (2021): e00731. doi: https://doi.org/10.1002/prp2.731
Gibson CR, Gleason A, Messina E. Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging. Pharmacol Res Perspect. 2021 Apr;9(2):e00731. doi: 10.1002/prp2.731. PMID: 33660925; PMCID: PMC7931129.
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Pharmacol Res Perspect. 2021 Apr;9(2):e00731. doi: 10.1002/prp2.731.

Measurement of total liver blood flow in intact anesthetized rats using ultrasound imaging.

Pharmacology research & perspectives

Christopher R Gibson, Alexa Gleason, Eric Messina

Affiliations

  1. Departments of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (CRG), Translational Biomarkers (AG, EM), Merck & Co., Inc., West Point, PA, USA.

PMID: 33660925 PMCID: PMC7931129 DOI: 10.1002/prp2.731

Abstract

This short report describes the measurement of total liver blood flow in commonly used laboratory rats using the relatively non-invasive approach of ultrasound imaging. A total of 29 rats (n = 26 Wistar-Han, n = 3 Sprague-Dawley) were imaged and both male and female rats were included. The mean (SD) total liver blood flow of all animals combined was 33.3 ± 7.8 mL/min, or 104.3 ± 17.1 mL/min/kg when normalized to observed body weight at the time of imaging. There was a trend for higher unnormalized total liver blood flow as body weight increased and the female rats had, in general, the lowest body weight and total liver blood flow of the animals studied. There were no major differences in total liver blood flow between the small number of Sprague-Dawley rats used in the study and the larger Wistar-Han group. Further research would be needed to accurately characterize any subtle differences in body weight between rats of different strains, sexes, and body weight.

© 2021 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

Keywords: blood flow; liver; rat; ultrasound

References

  1. J Pharmacokinet Biopharm. 1973 Apr;1(2):123-36 - PubMed
  2. J Appl Physiol. 1971 Oct;31(4):598-604 - PubMed
  3. Experientia. 1978 Aug 15;34(8):1061-2 - PubMed
  4. Biochem Pharmacol. 1976 Sep 1;25(17):1991-3 - PubMed
  5. Nat Rev Drug Discov. 2007 Feb;6(2):140-8 - PubMed
  6. Interface Focus. 2011 Aug 6;1(4):576-601 - PubMed
  7. Biochem Pharmacol. 1978;27(22):2617-21 - PubMed
  8. Environ Res. 2020 Mar;182:108948 - PubMed
  9. Clin Pharmacol Ther. 2015 Mar;97(3):247-62 - PubMed
  10. J Pharm Sci. 1983 Oct;72(10):1103-27 - PubMed
  11. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R707-20 - PubMed
  12. Ultrasound Int Open. 2015 Nov;1(2):E46-52 - PubMed
  13. Ann N Y Acad Sci. 1971 Jul 6;179:43-66 - PubMed
  14. J Med Ultrasound. 2018 Jan-Mar;26(1):3-13 - PubMed
  15. Clin Pharmacol Ther. 1975 Oct;18(4):377-90 - PubMed
  16. Anesthesiology. 1991 Mar;74(3):568-74 - PubMed

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