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Helke KL, Meyerholz DK, Beck AP, et al. Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats. ILAR J. 2021;doi: 10.1093/ilar/ilab005.
Helke, K. L., Meyerholz, D. K., Beck, A. P., Burrough, E. R., Derscheid, R. J., Löhr, C., McInnes, E. F., Scudamore, C. L., & Brayton, C. F. (2021). Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats. ILAR journal, . https://doi.org/10.1093/ilar/ilab005
Helke, Kristi L, et al. "Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats." ILAR journal vol. (2021). doi: https://doi.org/10.1093/ilar/ilab005
Helke KL, Meyerholz DK, Beck AP, Burrough ER, Derscheid RJ, Löhr C, McInnes EF, Scudamore CL, Brayton CF. Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats. ILAR J. 2021 Mar 13; doi: 10.1093/ilar/ilab005. Epub 2021 Mar 13. PMID: 33712827.
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ILAR J. 2021 Mar 13; doi: 10.1093/ilar/ilab005. Epub 2021 Mar 13.

Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats.

ILAR journal

Kristi L Helke, David K Meyerholz, Amanda P Beck, Eric R Burrough, Rachel J Derscheid, Christiane Löhr, Elizabeth F McInnes, Cheryl L Scudamore, Cory F Brayton

Affiliations

  1. Department of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
  2. Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  3. Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
  4. Veterinary Diagnostic and Production Animal Medicine Department, Iowa State University, Ames, Iowa, USA.
  5. Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, USA.
  6. Toxicologic Pathology, Toxicology Section, Human Safety at Syngenta, in Jealott's Hill, Bracknell, United Kingdom.
  7. ExePathology, Pathologist at ExePathology, Exmouth, Devon, United Kingdom.
  8. Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

PMID: 33712827 DOI: 10.1093/ilar/ilab005

Abstract

Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.

© The Author(s) 2021. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved. For permissions, please email: [email protected].

Keywords: anatomy; animal model; bacteria; infectious disease; neoplasia; pathology; physiology; spontaneous; virus

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