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Besci Ö, Başer D, Öğülür İ, et al. Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turk J Med Sci. 2021;51(4):1814-1824doi: 10.3906/sag-2010-176.
Besci, �. �., Başer, D., Öğülür, �. �., Berberoğlu, A. C., Kıykım, A., Besci, T., Leblebici, A., Ellidokuz, H., Boran, P., Özek, E., Haklar, G., Özen, A., Barış, S., & Aydıner, E. (2021). Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turkish journal of medical sciences, 51(4), 1814-1824. https://doi.org/10.3906/sag-2010-176
Besci, Özge, et al. "Reference values for T and B lymphocyte subpopulations in Turkish children and adults." Turkish journal of medical sciences vol. 51,4 (2021): 1814-1824. doi: https://doi.org/10.3906/sag-2010-176
Besci Ö, Başer D, Öğülür İ, Berberoğlu AC, Kıykım A, Besci T, Leblebici A, Ellidokuz H, Boran P, Özek E, Haklar G, Özen A, Barış S, Aydıner E. Reference values for T and B lymphocyte subpopulations in Turkish children and adults. Turk J Med Sci. 2021 Aug 30;51(4):1814-1824. doi: 10.3906/sag-2010-176. PMID: 33754649; PMCID: PMC8569764.
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Turk J Med Sci. 2021 Aug 30;51(4):1814-1824. doi: 10.3906/sag-2010-176.

Reference values for T and B lymphocyte subpopulations in Turkish children and adults.

Turkish journal of medical sciences

Özge Besci, Dilek Başer, İsmail Öğülür, Ayşe Cansu Berberoğlu, Ayça Kıykım, Tolga Besci, Asım Leblebici, Hülya Ellidokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Özen, Safa Barış, Elif Aydıner

Affiliations

  1. Department of Pediatric Allergy-Immunology, Faculty of Medicine, Marmara University, ?stanbul, Turkey
  2. Department of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylül University, ?zmir, Turkey
  3. Department of Pediatrics, Marmara University, Faculty of Medicine, ?stanbul, Turkey
  4. Department of Pediatric Intensive Care Unit, Faculty of Medicine, Dokuz Eylül University, ?zmir, Turkey
  5. Department of Translational Oncology, Faculty of Health Sciences, Dokuz Eylül University, ?zmir, Turkey
  6. Department of Biostatistics and Medical Informatics, Faculty of Medicine, Dokuz Eylül University, ?zmir, Turkey
  7. Department of Social Pediatrics, Faculty of Medicine University, Marmara University, ?stanbul, Turkey
  8. Department of Neonatology, Faculty of Medicine, Marmara University, ?stanbul, Turkey
  9. Department of Social Biochemistry, Faculty of Medicine, Marmara University, ?stanbul, Turkey

PMID: 33754649 PMCID: PMC8569764 DOI: 10.3906/sag-2010-176

Abstract

BACKGROUND/AIM: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish age- specific reference values for lymphocyte subsets using updated immunophenotyping panels.

MATERIALS AND METHODS: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed a complete blood count test and simultaneously with detailed immunophenotyping enumerated the percent and absolute cell counts of lymphocyte subsets.

RESULTS: The percentage and absolute counts of lymphocyte subsets show a marked surge across the age-span. T helper, T cytotoxic, and the natural killer cell numbers were increasing from birth until 6 months, followed by a gradual decrease thereafter. B cell numbers were rising until 2 years, followed by a gradual decrease for the upcoming years, accompanied by a steady expansion of unclass-switched- and class-switched- B cells.

CONCLUSION: We provide updated extensive reference intervals for lymphocyte subpopulations in Turkish people.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords: absolute count; lymphocyte percentage; lymphocyte subsets; reference values; Immunophenotyping

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