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Ellingjord-Dale M, Christakoudi S, Weiderpass E, et al. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Epidemiol. 2021;doi: 10.1093/ije/dyab032.
Ellingjord-Dale, M., Christakoudi, S., Weiderpass, E., Panico, S., Dossus, L., Olsen, A., Tjønneland, A., Kaaks, R., Schulze, M. B., Masala, G., Gram, I. T., Skeie, G., Rosendahl, A. H., Sund, M., Key, T., Ferrari, P., Gunter, M., Heath, A. K., Tsilidis, K. K., Riboli, E. (2021). Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. International journal of epidemiology, . https://doi.org/10.1093/ije/dyab032
Ellingjord-Dale, Merete, et al. "Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study." International journal of epidemiology vol. (2021). doi: https://doi.org/10.1093/ije/dyab032
Ellingjord-Dale M, Christakoudi S, Weiderpass E, Panico S, Dossus L, Olsen A, Tjønneland A, Kaaks R, Schulze MB, Masala G, Gram IT, Skeie G, Rosendahl AH, Sund M, Key T, Ferrari P, Gunter M, Heath AK, Tsilidis KK, Riboli E. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Epidemiol. 2021 Mar 23; doi: 10.1093/ije/dyab032. Epub 2021 Mar 23. PMID: 33755122.
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Int J Epidemiol. 2021 Mar 23; doi: 10.1093/ije/dyab032. Epub 2021 Mar 23.

Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

International journal of epidemiology

Merete Ellingjord-Dale, Sofia Christakoudi, Elisabete Weiderpass, Salvatore Panico, Laure Dossus, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, Matthias B Schulze, Giovanna Masala, Inger T Gram, Guri Skeie, Ann H Rosendahl, Malin Sund, Tim Key, Pietro Ferrari, Marc Gunter, Alicia K Heath, Konstantinos K Tsilidis, Elio Riboli,

Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK.
  2. MRC Centre for Transplantation, King's College London, London, UK.
  3. International Agency for Research on Cancer, World Health Organization, Lyon, France.
  4. Department of Clinical and Experimental Medicine, University of Naples Frederico II, Naples, Italy.
  5. Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  6. Department of Public Health, Aarhus University, Aarhus, Denmark.
  7. Danish Cancer Society, Research Center, Copenhagen, Denmark.
  8. Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.
  9. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  10. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  11. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
  12. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy.
  13. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
  14. Department of Clinical Sciences Lund, Division of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
  15. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
  16. Cancer Epidemiology Unit, Nuffield, Department of Population Health, University of Oxford, Oxford, UK.
  17. Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.

PMID: 33755122 DOI: 10.1093/ije/dyab032

Abstract

BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.

METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.

RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85).

CONCLUSION: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.

© The Author(s) 2021; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

Keywords: breast cancer; cohort study; long-term weight change

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