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Russo E, Viazzi F, Pontremoli R, et al. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project. J Nephrol. 2021;doi: 10.1007/s40620-021-00985-4.
Russo, E., Viazzi, F., Pontremoli, R., Barbagallo, C. M., Bombelli, M., Casiglia, E., Cicero, A. F. G., Cirillo, M., Cirillo, P., Desideri, G., D'Elia, L., Ferri, C., Galletti, F., Gesualdo, L., Giannattasio, C., Iaccarino, G., Leoncini, G., Mallamaci, F., Maloberti, A., Masi, S., Mengozzi, A., Mazza, A., Muiesan, M. L., Nazzaro, P., Palatini, P., Parati, G., Rattazzi, M., Rivasi, G., Salvetti, M., Tikhonoff, V., Tocci, G., Ungar, A., Verdecchia, P., Virdis, A., Volpe, M., Grassi, G., Borghi, C. (2021). Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project. Journal of nephrology, . https://doi.org/10.1007/s40620-021-00985-4
Russo, Elisa, et al. "Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project." Journal of nephrology vol. (2021). doi: https://doi.org/10.1007/s40620-021-00985-4
Russo E, Viazzi F, Pontremoli R, Barbagallo CM, Bombelli M, Casiglia E, Cicero AFG, Cirillo M, Cirillo P, Desideri G, D'Elia L, Ferri C, Galletti F, Gesualdo L, Giannattasio C, Iaccarino G, Leoncini G, Mallamaci F, Maloberti A, Masi S, Mengozzi A, Mazza A, Muiesan ML, Nazzaro P, Palatini P, Parati G, Rattazzi M, Rivasi G, Salvetti M, Tikhonoff V, Tocci G, Ungar A, Verdecchia P, Virdis A, Volpe M, Grassi G, Borghi C. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project. J Nephrol. 2021 Mar 23; doi: 10.1007/s40620-021-00985-4. Epub 2021 Mar 23. PMID: 33755930.
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J Nephrol. 2021 Mar 23; doi: 10.1007/s40620-021-00985-4. Epub 2021 Mar 23.

Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project.

Journal of nephrology

Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Carlo Maria Barbagallo, Michele Bombelli, Edoardo Casiglia, Arrigo Francesco Giuseppe Cicero, Massimo Cirillo, Pietro Cirillo, Giovambattista Desideri, Lanfranco D'Elia, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Iaccarino, Giovanna Leoncini, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Alessandro Mengozzi, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Marcello Rattazzi, Giulia Rivasi, Massimo Salvetti, Valérie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Guido Grassi, Claudio Borghi,

Affiliations

  1. Department of Internal Medicine, University of Genoa and IRCCS Ospdedale Policlinico San Martino, Viale Benedetto XV, 6, 16132, Genoa, Italy.
  2. Department of Internal Medicine, University of Genoa and IRCCS Ospdedale Policlinico San Martino, Viale Benedetto XV, 6, 16132, Genoa, Italy. [email protected].
  3. Biomedical Department of Internal Medicine and Specialistics, University of Palermo, Palermo, Italy.
  4. Department of Medicine and Surgery, Clinica Medica, University of Milano-Bicocca, Monza, Italy.
  5. Department of Medicine, Studium Patavinum, University of Padua, Padua, Italy.
  6. Department of Medical and Surgical Science, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  7. Department of Public Health, Federico II University of Naples Medical School, Naples, Italy.
  8. Department of Emergency and Organ Transplantation-Nephrology, Dialysis and Transplantation Unit, Aldo Moro University of Bari, Bari, Italy.
  9. Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  10. Department of Clinical Medicine and Surgery, Federico II University of Naples Medical School, Naples, Italy.
  11. Cardiology IV, A. De Gasperis Department, Health Science Department, Niguarda Ca' Granda Hospital, Milano-Bicocca University, Milan, Italy.
  12. Department of Advanced Biomedical Sciences, Federico II University of Naples Medical School, Naples, Italy.
  13. Reggio Cal Unit, CNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
  14. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  15. Department of Internal Medicine, Hypertension Unit, General Hospital, Rovigo, Italy.
  16. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  17. Department of Medical Basic Sciences, Neurosciences and Sense Organs, University of Bari Medical School, Bari, Italy.
  18. S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy.
  19. Department of Medicine, Medicina Interna 1°, Ca' Foncello University Hospital, University of Padova, Treviso, Italy.
  20. Department of Medicine, University of Padua, Padua, Italy.
  21. Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
  22. IRCCS Neuromed, Pozzilli, Italy.
  23. Department of Geriatric and Intensive Care Medicine, Careggi Hospital and University of Florence, Florence, Italy.
  24. Hospital S. Maria della Misericordia, Perugia, Italy.

PMID: 33755930 DOI: 10.1007/s40620-021-00985-4

Abstract

BACKGROUND: Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database.

METHODS: Clinical data of 26,971 individuals were analyzed. Factors associated with the presence of hyperuricemia defined on the basis of previously determined URRAH cutoffs for cardiovascular and all-cause mortality were evaluated through multivariate analysis. Chronic kidney disease was defined as eGFR < 60 ml/min per 1.73 m

RESULTS: Mean age was 58 ± 15 years (51% males, 62% with hypertension and 12% with diabetes), mean eGFR was 81 ml/min per 1.73m2

CONCLUSIONS: The lower the eGFR the higher the prevalence of hyperuricemia and gout. In subjects with eGFR < 60 ml/min the occurrence of hyperuricemia is about 10 times higher than in those with eGFR > 90 ml/min. The percentage of individuals treated with allopurinol was below 2% when GFR was above 60 ml/min, it increased to 20% in the presence of CKD 3b and rose further to 35% in individuals with macroalbuminuria.

Keywords: Albuminuria; Cardiovascular risk; Serum uric acid; eGFR

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