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Malézieux E, Meunier L, Rivière B, et al. Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI. Clin Res Hepatol Gastroenterol. 2021;45(5):101599doi: 10.1016/j.clinre.2020.101599.
Malézieux, E., Meunier, L., Rivière, B., & Larrey, D. (2021). Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI. Clinics and research in hepatology and gastroenterology, 45(5), 101599. https://doi.org/10.1016/j.clinre.2020.101599
Malézieux, Emilie, et al. "Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI." Clinics and research in hepatology and gastroenterology vol. 45,5 (2021): 101599. doi: https://doi.org/10.1016/j.clinre.2020.101599
Malézieux E, Meunier L, Rivière B, Larrey D. Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI. Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101599. doi: 10.1016/j.clinre.2020.101599. Epub 2021 Mar 03. PMID: 33676268.
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Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101599. doi: 10.1016/j.clinre.2020.101599. Epub 2021 Mar 03.

Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI.

Clinics and research in hepatology and gastroenterology

Emilie Malézieux, Lucy Meunier, Benjamin Rivière, Dominique Larrey

Affiliations

  1. Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France.
  2. Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France. Electronic address: [email protected].
  3. Department of Pathology, St-Eloi University Hospital, Montpellier, France.

PMID: 33676268 DOI: 10.1016/j.clinre.2020.101599

Abstract

Thiazide diuretics are prescribed daily and rarely hepatotoxic. We report the case of 86-year-old woman who was admitted in hospital for jaundice after taking hydrochlorothiazide. All differential diagnoses have been eliminated. The liver biopsy was compatible with drug-induced hepatitis. Clinical and biological manifestations improved after discontinuation of the treatment. The reported case is compared to three other cases in the literature.

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Keywords: Acute hepatitis; DILI; Hepatotoxicity; Hydrochlorothiazide; Thiazide diuretics

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