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Defize IL, Gorgels SMC, Mazza E, et al. The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study. Ann Thorac Surg. 2021;doi: 10.1016/j.athoracsur.2021.02.041.
Defize, I. L., Gorgels, S. M. C., Mazza, E., Schurink, B., Strignano, P., Catalano, G., Brosens, L. A. A., Chiusa, L., Bleys, R. L. A. W., Mook, S., Meijer, G. J., Romagnoli, R., Ruurda, J. P., & van Hillegersberg, R. (2021). The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study. The Annals of thoracic surgery, . https://doi.org/10.1016/j.athoracsur.2021.02.041
Defize, Ingmar L, et al. "The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study." The Annals of thoracic surgery vol. (2021). doi: https://doi.org/10.1016/j.athoracsur.2021.02.041
Defize IL, Gorgels SMC, Mazza E, Schurink B, Strignano P, Catalano G, Brosens LAA, Chiusa L, Bleys RLAW, Mook S, Meijer GJ, Romagnoli R, Ruurda JP, van Hillegersberg R. The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study. Ann Thorac Surg. 2021 Mar 04; doi: 10.1016/j.athoracsur.2021.02.041. Epub 2021 Mar 04. PMID: 33676903.
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Ann Thorac Surg. 2021 Mar 04; doi: 10.1016/j.athoracsur.2021.02.041. Epub 2021 Mar 04.

The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study.

The Annals of thoracic surgery

Ingmar L Defize, Stijn M C Gorgels, Elena Mazza, Bernadette Schurink, Paolo Strignano, Giorgia Catalano, Lodewijk A A Brosens, Luigi Chiusa, Ronald L A W Bleys, Stella Mook, Gert J Meijer, Renato Romagnoli, Jelle P Ruurda, Richard van Hillegersberg

Affiliations

  1. Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
  2. Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
  3. General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
  4. Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Anatomy, University Medical Center Utrecht, Utrecht, the Netherlands.
  5. Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
  6. Department of Pathology, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
  7. Department of Anatomy, University Medical Center Utrecht, Utrecht, the Netherlands.
  8. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
  9. Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: [email protected].

PMID: 33676903 DOI: 10.1016/j.athoracsur.2021.02.041

Abstract

BACKGROUND: The thoracic lymphadenectomy during an esophagectomy for esophageal cancer includes resection of the thoracic duct (TD) compartment containing the TD lymph nodes (TDLNs). The role of TD compartment resection is still a topic of debate since metastatic TDLNs have only been demonstrated in squamous cell carcinomas in Eastern esophageal cancer patients. Therefore, the aim of this study was to assess the presence and metastatic involvement of TDLNs in a Western population, in which adenocarcinoma is the predominant type of esophageal cancer.

METHODS: From July 2017 to May 2020, all consecutive patients undergoing an open or robot-assisted transthoracic esophagectomy with concurrent lymphadenectomy and resection of the TD compartment in the University Medical Center Utrecht in Utrecht, the Netherlands, and the Città della Salute e della Scienza University Hospital in Turin, Italy, were included. The TD compartment was resected en bloc and was separated in the operation room by the operating surgeon after which it was macroscopically and microscopically assessed for (metastatic) TDLNs by the pathologist.

RESULTS: A total of 117 patients with an adenocarcinoma (73%) or squamous cell carcinoma (27%) of the esophagus were included. In 61 (52%) patients, TDLNs were found, containing metastasis in 9 (15%) patients. No major complications related to TD compartment resection were observed.

CONCLUSIONS: This study demonstrates the presence of metastatic TDLNs in adenocarcinomas of the esophagus. This result provides a valid argument to routinely extend the thoracic lymphadenectomy with resection of the TD compartment during an esophagectomy for esophageal cancer.

Copyright © 2021 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

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