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Díaz P, Sandoval-Bórquez A, Bravo-Sagua R, et al. Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease. Front Cell Dev Biol. 2021;9:613336doi: 10.3389/fcell.2021.613336.
Díaz, P., Sandoval-Bórquez, A., Bravo-Sagua, R., Quest, A. F. G., & Lavandero, S. (2021). Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease. Frontiers in cell and developmental biology, 9613336. https://doi.org/10.3389/fcell.2021.613336
Díaz, Paula, et al. "Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease." Frontiers in cell and developmental biology vol. 9 (2021): 613336. doi: https://doi.org/10.3389/fcell.2021.613336
Díaz P, Sandoval-Bórquez A, Bravo-Sagua R, Quest AFG, Lavandero S. Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease. Front Cell Dev Biol. 2021 Feb 25;9:613336. doi: 10.3389/fcell.2021.613336. eCollection 2021. PMID: 33718356; PMCID: PMC7946981.
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Front Cell Dev Biol. 2021 Feb 25;9:613336. doi: 10.3389/fcell.2021.613336. eCollection 2021.

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease.

Frontiers in cell and developmental biology

Paula Díaz, Alejandra Sandoval-Bórquez, Roberto Bravo-Sagua, Andrew F G Quest, Sergio Lavandero

Affiliations

  1. Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.
  2. Center for Studies on Exercise, Metabolism and Cancer (CEMC), Program of Cell and Molecular Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM), Universidad de Chile, Santiago, Chile.
  3. Institute of Nutrition and Food Technology (INTA), Universidad de Chile, Santiago, Chile.
  4. Corporación Centro de Estudios Científicos de las Enfermedades Crónicas (CECEC), Santiago, Chile.
  5. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.

PMID: 33718356 PMCID: PMC7946981 DOI: 10.3389/fcell.2021.613336

Abstract

In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although high-throughput techniques facilitate identification of novel contact sites (e.g., organelle-organelle and organelle-vesicle interactions), little is known about their impact on cellular physiology. Moreover, even less is known about how the dysregulation of these structures impacts on cellular function and therefore, disease. Particularly, cancer cells display altered signaling pathways involving several cell organelles; however, the relevance of interorganelle communication in oncogenesis and/or cancer progression remains largely unknown. This review will focus on organelle contacts relevant to cancer pathogenesis. We will highlight specific proteins and protein families residing in these organelle-interfaces that are known to be involved in cancer-related processes. First, we will review the relevance of endoplasmic reticulum (ER)-mitochondria interactions. This section will focus on mitochondria-associated membranes (MAMs) and particularly the tethering proteins at the ER-mitochondria interphase, as well as their role in cancer disease progression. Subsequently, the role of Ca

Copyright © 2021 Díaz, Sandoval-Bórquez, Bravo-Sagua, Quest and Lavandero.

Keywords: cancer; endoplasmic reticulum; interorganelle communication; lysosome; mitochondria; peroxisome

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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