Ter Arkh. 2020 Dec 15;92(12):91-96. doi: 10.26442/00403660.2020.12.200470.

[Mixed steatohepatitis: more questions than answers (Part 1)].

Terapevticheskii arkhiv

[Article in Russian]
K L Raikhelson, E A Kondrashina, E V Pazenko

PMID: 33720580 DOI: 10.26442/00403660.2020.12.200470

Abstract

The term steatohepatitis is used for a heterogeneous group of diseases of various etiologies, characterized by a similar morphological picture. Earlier the diagnosis of non-alcoholic fatty liver disease implied the exclusion of other causes of steatohepatitis, in recent years it has been suggested that a combination of various etiological variants of steatohepatitis is possible. The review considers the terminological, epidemiological and pathogenetic aspects of the most common combination: metabolic and alcoholic genesis, the issues of the mutual influence of etiopathogenetic factors and the identification of the predominant process. Issues of existing and prospective pathogenetic and symptomatic therapy are discussed in detail. Treatment of steatohepatitis is based on the elimination of known causal factors and lifestyle modification; therapy includes medications, that have been proven to be effective in certain types of steatohepatitis and symptomatic therapy as well.

Keywords: ademetionine; alcoholic liver disease; drug-induced liver injury; non-alcoholic fatty liver disease; steatohepatitis

MeSH terms

• Humans
• Life Style
• Non-alcoholic Fatty Liver Disease* / diagnosis
• Non-alcoholic Fatty Liver Disease* / epidemiology
• Non-alcoholic Fatty Liver Disease* / etiology
• Prospective Studies

Publication Types

• Classical Article