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Asl AA, Lankarani KB, Nikeghbalian S, et al. Post liver transplant complications of Budd-Chiari syndrome. Indian J Gastroenterol. 2021;40(3):281-286doi: 10.1007/s12664-020-01139-3.
Asl, A. A., Lankarani, K. B., Nikeghbalian, S., Kazemi, K., Shamsaieefar, A., Alizade-Naini, M., Fattahi, M. R., Taghavi, S. A., Niknam, R., Ejtehadi, F., Dehghan, M., Sivandzadeh, G., Ghahramani, S., & Malek-Hosseini, S. A. (2021). Post liver transplant complications of Budd-Chiari syndrome. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 40(3), 281-286. https://doi.org/10.1007/s12664-020-01139-3
Asl, Ali Ansari, et al. "Post liver transplant complications of Budd-Chiari syndrome." Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology vol. 40,3 (2021): 281-286. doi: https://doi.org/10.1007/s12664-020-01139-3
Asl AA, Lankarani KB, Nikeghbalian S, Kazemi K, Shamsaieefar A, Alizade-Naini M, Fattahi MR, Taghavi SA, Niknam R, Ejtehadi F, Dehghan M, Sivandzadeh G, Ghahramani S, Malek-Hosseini SA. Post liver transplant complications of Budd-Chiari syndrome. Indian J Gastroenterol. 2021 Jun;40(3):281-286. doi: 10.1007/s12664-020-01139-3. Epub 2021 Mar 20. PMID: 33743161.
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Indian J Gastroenterol. 2021 Jun;40(3):281-286. doi: 10.1007/s12664-020-01139-3. Epub 2021 Mar 20.

Post liver transplant complications of Budd-Chiari syndrome.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Ali Ansari Asl, Kamran B Lankarani, Saman Nikeghbalian, Koroush Kazemi, Alireza Shamsaieefar, Mahvash Alizade-Naini, Mohamad Reza Fattahi, Seyed Alireza Taghavi, Ramin Niknam, Fardad Ejtehadi, Masood Dehghan, Gholamreza Sivandzadeh, Sulmaz Ghahramani, Seyed Ali Malek-Hosseini

Affiliations

  1. Shiraz Transplant Research Center, Shiraz University of Medical sciences, Shiraz, Islamic Republic of Iran.
  2. Health Policy research center, School of Medicine, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. [email protected].
  3. Gastroenterohepatology Research Center, Shiraz University of Medical sciences, Shiraz, Islamic Republic of Iran.
  4. Health Policy research center, School of Medicine, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.

PMID: 33743161 DOI: 10.1007/s12664-020-01139-3

Abstract

BACKGROUND/PURPOSE: Budd-Chiari syndrome (BCS) is a rare, life-threatening disease characterized by hepatic venous outflow obstruction. Liver transplantation (LT) is widely accepted as an effective therapeutic measure for irreversible liver failure due to BCS. There is debate on differences in the post LT course and complications in patients with BCS as compared to non-Budd-Chiari (NBC) patients.

METHOD: In this retrospective study, data on all patients who received a liver transplant for BCS at the Shiraz Organ Transplantation Center between January 1996 and September 2017 were reviewed and compared to data of a control group who had received liver transplants over the same period but due to other causes (NBC).

RESULTS: Out of 4225 patients who received liver transplants in the study period, 108 had BCS and an age- and gender-matched control group consisted of 108 NBC cases. The mean ± standard deviation (SD) of model for end-stage liver disease (MELD) scores were 19.1 ± 3 and 20 ± 3 for BCS and NBC groups, respectively (p = 0.33). One-, 3-, 5-, and 10-year survival rates in the BCS group were as follows: 82%, 78%, 76%, and 76% compared with the NBC rates of 83%, 83%, 83%, and 76%, respectively (p = 0.556). There was no difference between the two groups in complication rates after 6 months. In the later period, vascular thrombosis was more common in BCS.

CONCLUSIONS: Whole-organ LT from deceased donors in patients with BCS had comparable outcomes with LT due to other causes of end-stage liver disease. In most instances, these patients should receive lifelong anticoagulation.

Keywords: Anticoagulants; Deceased organ donor; End-stage liver disease; Hepatic venous thrombosis; Iran; Liver cirrhosis; Liver failure; Liver transplantation; Myeloproliferative neoplasms

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