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Peres J, Damerell V, Chauhan J, et al. TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF. J Invest Dermatol. 2021;141(9):2250-2260.e2doi: 10.1016/j.jid.2021.02.740.
Peres, J., Damerell, V., Chauhan, J., Popovic, A., Desprez, P. Y., Galibert, M. D., Goding, C. R., & Prince, S. (2021). TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF. The Journal of investigative dermatology, 141(9), 2250-2260.e2. https://doi.org/10.1016/j.jid.2021.02.740
Peres, Jade, et al. "TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF." The Journal of investigative dermatology vol. 141,9 (2021): 2250-2260.e2. doi: https://doi.org/10.1016/j.jid.2021.02.740
Peres J, Damerell V, Chauhan J, Popovic A, Desprez PY, Galibert MD, Goding CR, Prince S. TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF. J Invest Dermatol. 2021 Sep;141(9):2250-2260.e2. doi: 10.1016/j.jid.2021.02.740. Epub 2021 Mar 17. PMID: 33744299.
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J Invest Dermatol. 2021 Sep;141(9):2250-2260.e2. doi: 10.1016/j.jid.2021.02.740. Epub 2021 Mar 17.

TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF.

The Journal of investigative dermatology

Jade Peres, Victoria Damerell, Jagat Chauhan, Ana Popovic, Pierre-Yves Desprez, Marie-Dominique Galibert, Colin R Goding, Sharon Prince

Affiliations

  1. Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
  2. Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, Oxford United Kingdom.
  3. California Pacific Medical Center, Research Institute, San Francisco, California, USA.
  4. IGDR (Institut de Génétique et Développement de Rennes) - UMR6290, CNRS, University of Rennes, Rennes, France; Department of Molecular Genetics and Genomics, Hospital University of Rennes (CHU Rennes), Rennes, France.
  5. Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Electronic address: [email protected].

PMID: 33744299 DOI: 10.1016/j.jid.2021.02.740

Abstract

In melanoma, a phenotype switch from proliferation to invasion underpins metastasis, the major cause of melanoma-associated death. The transition from radial to vertical growth phase (invasive) melanoma is characterized by downregulation of both E-cadherin (CDH1) and MITF and upregulation of the key cancer-associated gene TBX3 and the phosphatidylinositol 3 kinase signaling pathway. Yet, whether and how these diverse events are linked remains poorly understood. Here, we show that TBX3 directly promotes expression of ID1, a dominant-negative regulator of basic helix-loop-helix transcription factors, and that ID1 decreases MITF binding and upregulation of CDH1. Significantly, we show that TBX3 activation of ID1 is necessary for TBX3 to enhance melanoma cell migration, and the mechanistic links between TBX3, ID1, MITF, and invasion revealed here are reflected in their expression in human melanomas. Our results reveal that melanoma migration is promoted through a TBX3-ID1-MITF-E-cadherin axis and that ID1-mediated repression of MITF activity may reinforce maintenance of an MITF

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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