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Coleman RC, Eguchi A, Lieu M, et al. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Sci Signal. 2021;14(676)doi: 10.1126/scisignal.abb5968.
Coleman, R. C., Eguchi, A., Lieu, M., Roy, R., Barr, E. W., Ibetti, J., Lucchese, A. M., Peluzzo, A. M., Gresham, K., Chuprun, J. K., & Koch, W. J. (2021). A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Science signaling, 14(676), . https://doi.org/10.1126/scisignal.abb5968
Coleman, Ryan C, et al. "A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure." Science signaling vol. 14,676 (2021). doi: https://doi.org/10.1126/scisignal.abb5968
Coleman RC, Eguchi A, Lieu M, Roy R, Barr EW, Ibetti J, Lucchese AM, Peluzzo AM, Gresham K, Chuprun JK, Koch WJ. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Sci Signal. 2021 Mar 30;14(676). doi: 10.1126/scisignal.abb5968. PMID: 33785612; PMCID: PMC8092419.
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Sci Signal. 2021 Mar 30;14(676). doi: 10.1126/scisignal.abb5968.

A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.

Science signaling

Ryan C Coleman, Akito Eguchi, Melissa Lieu, Rajika Roy, Eric W Barr, Jessica Ibetti, Anna-Maria Lucchese, Amanda M Peluzzo, Kenneth Gresham, J Kurt Chuprun, Walter J Koch

Affiliations

  1. Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
  2. Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. [email protected].

PMID: 33785612 PMCID: PMC8092419 DOI: 10.1126/scisignal.abb5968

Abstract

Aberrant changes in gene expression underlie the pathogenesis and progression of pressure-overload heart failure, leading to maladaptive cardiac hypertrophy, ventricular remodeling, and contractile dysfunction. Signaling through the G protein G

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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