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Shelton HW, Gabbita SP, Gill WD, et al. The effects of a novel inhibitor of tumor necrosis factor (TNF) alpha on prepulse inhibition and microglial activation in two distinct rodent models of schizophrenia. Behav Brain Res. 2021;406:113229doi: 10.1016/j.bbr.2021.113229.
Shelton, H. W., Gabbita, S. P., Gill, W. D., Burgess, K. C., Whicker, W. S., & Brown, R. W. (2021). The effects of a novel inhibitor of tumor necrosis factor (TNF) alpha on prepulse inhibition and microglial activation in two distinct rodent models of schizophrenia. Behavioural brain research, 406113229. https://doi.org/10.1016/j.bbr.2021.113229
Shelton, Heath W, et al. "The effects of a novel inhibitor of tumor necrosis factor (TNF) alpha on prepulse inhibition and microglial activation in two distinct rodent models of schizophrenia." Behavioural brain research vol. 406 (2021): 113229. doi: https://doi.org/10.1016/j.bbr.2021.113229
Shelton HW, Gabbita SP, Gill WD, Burgess KC, Whicker WS, Brown RW. The effects of a novel inhibitor of tumor necrosis factor (TNF) alpha on prepulse inhibition and microglial activation in two distinct rodent models of schizophrenia. Behav Brain Res. 2021 May 21;406:113229. doi: 10.1016/j.bbr.2021.113229. Epub 2021 Mar 05. PMID: 33684425.
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Behav Brain Res. 2021 May 21;406:113229. doi: 10.1016/j.bbr.2021.113229. Epub 2021 Mar 05.

The effects of a novel inhibitor of tumor necrosis factor (TNF) alpha on prepulse inhibition and microglial activation in two distinct rodent models of schizophrenia.

Behavioural brain research

Heath W Shelton, S Prasad Gabbita, W Drew Gill, Katherine C Burgess, Wyatt S Whicker, Russell W Brown

Affiliations

  1. Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States.
  2. P2D Bioscience, Inc., Cincinnati, OH, United States.
  3. Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States. Electronic address: [email protected].

PMID: 33684425 DOI: 10.1016/j.bbr.2021.113229

Abstract

Increased neuroinflammation has been shown in individuals diagnosed with schizophrenia (SCHZ). This study evaluated a novel immune modulator (PD2024) that targets the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFα) to alleviate sensorimotor gating deficits and microglial activation employing two different rodent models of SCHZ. In Experiment 1, rats were neonatally treated with saline or the dopamine D

Copyright © 2021. Published by Elsevier B.V.

Keywords: Dopamine D2 receptor; Microglia; Neuroinflammation; Poly I:C; Prepulse inhibition; Schizophrenia; Sensorimotor gating; Tumor necrosis factor-alpha (TNFα)

Publication Types

Grant support