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Front Oncol. 2021 Mar 09;11:612903. doi: 10.3389/fonc.2021.612903. eCollection 2021.

[No title available]

Frontiers in oncology

Alicia S Ombredane, Vitória R P Silva, Laise R Andrade, Willie O Pinheiro, Mayara Simonelly, Jaqueline V Oliveira, Andréia C Pinheiro, Gabriel F Gonçalves, Gisela J Felice, Mônica P Garcia, Patrícia M Campos, Glécia V S Luz, Graziella A Joanitti

Affiliations

  1. Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), University of Brasilia, Brasilia, Brazil.
  2. Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
  3. Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil.
  4. Post-Graduation Program in Sciences and Technologies in Health, Faculty of Ceilandia, University of Brasilia, Brasilia, Brazil.
  5. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
  6. Pharmaceutical Sciences Department, State University of Ponta Grossa, Parana, Brazil.
  7. Post-Graduate Program in Biomedical Engineering-PPGEB, Faculty of Gama-FGA, University of Brasilia, Brasilia, Brazil.
  8. Health Technology Assessment Center-NATS/UnB, University of Brasília, Brasilia, Brazil.

PMID: 33767985 PMCID: PMC7986721 DOI: 10.3389/fonc.2021.612903

Abstract

Breast cancer is one of the most prevalent types of malignant tumors in the world, resulting in a high incidence of death. The development of new molecules and technologies aiming to apply more effective and safer therapy strategies has been intensively explored to overcome this situation. The association of nanoparticles with known antitumor compounds (including plant-derived molecules such as curcumin) has been considered an effective approach to enhance tumor growth suppression and reduce adverse effects. Therefore, the objective of this systematic review was to summarize published data regarding evaluations about efficacy and toxicity of curcumin nanoparticles (Cur-NPs) in

Copyright © 2021 Ombredane, Silva, Andrade, Pinheiro, Simonelly, Oliveira, Pinheiro, Gonçalves, Felice, Garcia, Campos, Luz and Joanitti.

Keywords: antitumor; apoptosis; breast cancer; curcumin; in vivo; nanoparticle; systematic review; toxicity

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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