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Rizk SA, El-Hashash MA, Youssef AA, et al. A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions. Heliyon. 2021;7(3):e06220doi: 10.1016/j.heliyon.2021.e06220.
Rizk, S. A., El-Hashash, M. A., Youssef, A. A., & Elgendy, A. T. (2021). A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions. Heliyon, 7(3), e06220. https://doi.org/10.1016/j.heliyon.2021.e06220
Rizk, Sameh A, et al. "A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions." Heliyon vol. 7,3 (2021): e06220. doi: https://doi.org/10.1016/j.heliyon.2021.e06220
Rizk SA, El-Hashash MA, Youssef AA, Elgendy AT. A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions. Heliyon. 2021 Mar 08;7(3):e06220. doi: 10.1016/j.heliyon.2021.e06220. eCollection 2021 Mar. PMID: 33748447; PMCID: PMC7969343.
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Heliyon. 2021 Mar 08;7(3):e06220. doi: 10.1016/j.heliyon.2021.e06220. eCollection 2021 Mar.

A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions.

Heliyon

Sameh A Rizk, Maher A El-Hashash, Amr A Youssef, Abdelfattah T Elgendy

Affiliations

  1. Organic Chemistry, Chemistry Department, Science Faculty, Ain-Shams University, Egypt.
  2. Mathematic Department, Science Department, Ain-Shams University, 11566, Cairo, Egypt.
  3. Physics Department, Science Department, Ain-Shams University, 11566, Cairo, Egypt.

PMID: 33748447 PMCID: PMC7969343 DOI: 10.1016/j.heliyon.2021.e06220

Abstract

Conventional synthesis of the phthalazine has already allowed affording the phthalazin-1-one phthalazin-1-ol dynamic equilibrium that decreases the anticancer activity due to diminishing the concentration of the phthalazin-1-ol product. Nowadays, pure phthalazin-1-ol (

© 2021 The Authors.

Keywords: Anticancer HepG2; Arrhenius model; DFT simulation; Efficient green microwave synthesis; HCT-116 and MCF-7; Phthalazin-1(2H)-ol

Conflict of interest statement

The authors declare no conflict of interest.

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