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Kustova MV, Perfilova VN, Prokofiev II, et al. Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication. Bull Exp Biol Med. 2021;170(5):631-635doi: 10.1007/s10517-021-05121-7.
Kustova, M. V., Perfilova, V. N., Prokofiev, I. I., & Tyurenkov, I. N. (2021). Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication. Bulletin of experimental biology and medicine, 170(5), 631-635. https://doi.org/10.1007/s10517-021-05121-7
Kustova, M V, et al. "Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication." Bulletin of experimental biology and medicine vol. 170,5 (2021): 631-635. doi: https://doi.org/10.1007/s10517-021-05121-7
Kustova MV, Perfilova VN, Prokofiev II, Tyurenkov IN. Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication. Bull Exp Biol Med. 2021 Mar;170(5):631-635. doi: 10.1007/s10517-021-05121-7. Epub 2021 Mar 31. PMID: 33788110.
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Bull Exp Biol Med. 2021 Mar;170(5):631-635. doi: 10.1007/s10517-021-05121-7. Epub 2021 Mar 31.

Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication.

Bulletin of experimental biology and medicine

M V Kustova, V N Perfilova, I I Prokofiev, I N Tyurenkov

Affiliations

  1. Volgograd State Medical University of the Ministry of Health of Russian Federation, Volgograd, Russia. [email protected].
  2. Volgograd State Medical University of the Ministry of Health of Russian Federation, Volgograd, Russia.

PMID: 33788110 DOI: 10.1007/s10517-021-05121-7

Abstract

The effect of a new derivative of GABA, the compound RGPU-260, on the heart contractility of rats exposed to chronic alcohol intoxication (10% ethanol solution for 24 weeks) was studied. In comparison with intact rats, the alcoholized ones were characterized with smaller increments in the rates of myocardial contraction (+dP/dt

Keywords: cardioprotective effects; chronic alcohol intoxication; derivatives of GABA

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