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Shmookler Reis RJ, Atluri R, Balasubramaniam M, et al. "Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation. Aging Cell. 2021;20(5):e13326doi: 10.1111/acel.13326.
Shmookler Reis, R. J., Atluri, R., Balasubramaniam, M., Johnson, J., Ganne, A., & Ayyadevara, S. (2021). "Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation. Aging cell, 20(5), e13326. https://doi.org/10.1111/acel.13326
Shmookler Reis, Robert J, et al. ""Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation." Aging cell vol. 20,5 (2021): e13326. doi: https://doi.org/10.1111/acel.13326
Shmookler Reis RJ, Atluri R, Balasubramaniam M, Johnson J, Ganne A, Ayyadevara S. "Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation. Aging Cell. 2021 May;20(5):e13326. doi: 10.1111/acel.13326. Epub 2021 Mar 31. PMID: 33788386; PMCID: PMC8135009.
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Aging Cell. 2021 May;20(5):e13326. doi: 10.1111/acel.13326. Epub 2021 Mar 31.

"Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation.

Aging cell

Robert J Shmookler Reis, Ramani Atluri, Meenakshisundaram Balasubramaniam, Jay Johnson, Akshatha Ganne, Srinivas Ayyadevara

Affiliations

  1. Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.
  2. Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  3. BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA.

PMID: 33788386 PMCID: PMC8135009 DOI: 10.1111/acel.13326

Abstract

All neurodegenerative diseases feature aggregates, which usually contain disease-specific diagnostic proteins; non-protein constituents, however, have rarely been explored. Aggregates from SY5Y-APP

© 2021 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. Published 2021. This article is a U.S. Government work and is in the public domain in the USA.

Keywords: Alzheimer’s disease; DNA; RNA; aggregation; apolipoprotein E; beta amyloid; cotranslational misfolding; endogenous viruses; functional annotation; gene ontology; neurodegeneration; nucleic acid sequence; nucleic acids; protein aggregates; proteomics; retrotransposons

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