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Rodriguez-Graña T, Rodríguez-Labrada R, Santana-Porbén S, et al. Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study. Nutr Neurosci. 2021;1-9doi: 10.1080/1028415X.2021.1895479.
Rodriguez-Graña, T., Rodríguez-Labrada, R., Santana-Porbén, S., Reynaldo-Cejas, L., Medrano-Montero, J., Canales-Ochoa, N., Silva-Ricardo, Y., Torres-Vega, R., González-Zaldivar, Y., Almaguer-Gotay, D., Auburger, G., & Velázquez-Pérez, L. (2021). Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study. Nutritional neuroscience, 1-9. https://doi.org/10.1080/1028415X.2021.1895479
Rodriguez-Graña, Tania, et al. "Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study." Nutritional neuroscience vol. (2021): 1-9. doi: https://doi.org/10.1080/1028415X.2021.1895479
Rodriguez-Graña T, Rodríguez-Labrada R, Santana-Porbén S, Reynaldo-Cejas L, Medrano-Montero J, Canales-Ochoa N, Silva-Ricardo Y, Torres-Vega R, González-Zaldivar Y, Almaguer-Gotay D, Auburger G, Velázquez-Pérez L. Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study. Nutr Neurosci. 2021 Mar 09;1-9. doi: 10.1080/1028415X.2021.1895479. Epub 2021 Mar 09. PMID: 33687306.
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Nutr Neurosci. 2021 Mar 09;1-9. doi: 10.1080/1028415X.2021.1895479. Epub 2021 Mar 09.

Weight loss is correlated with disease severity in Spinocerebellar ataxia type 2: a cross-sectional cohort study.

Nutritional neuroscience

Tania Rodriguez-Graña, Roberto Rodríguez-Labrada, Sergio Santana-Porbén, Lorenzo Reynaldo-Cejas, Jacqueline Medrano-Montero, Nalia Canales-Ochoa, Yanelis Silva-Ricardo, Reidenis Torres-Vega, Yanetza González-Zaldivar, Dennis Almaguer-Gotay, Georg Auburger, Luis Velázquez-Pérez

Affiliations

  1. Centre for the Research and Rehabilitation of Hereditary Ataxias, El Llano, Holguin, Cuba.
  2. Medical University of Holguin, Holguin, Cuba.
  3. Cuban Neuroscience Centre, La Havana, Cuba.
  4. School of Medicine of Havana, Havana, Cuba.
  5. Clinical & Surgical Hospital "Lucia Iniguez", Holguin, Cuba.
  6. Exp. Neurology, Medical Faculty, Goethe University, Frankfurt am Main, Germany.
  7. Cuban Academy of Sciences, La Habana, Cuba.

PMID: 33687306 DOI: 10.1080/1028415X.2021.1895479

Abstract

BACKGROUND: Body weight changes occur frequently during advanced stages of Spinocerebellar Ataxia type 2 (SCA2), nevertheless limited information exists on biomarkers of nutritional status of these patients.

OBJECTIVE.: To assess changes in surrogate nutritional markers of SCA2 patients; to explore their associations with expanded CAG repeats and disease severity.

METHODS: One-hundred-thirteen SCA2 patients and 50 healthy controls underwent a comprehensive anthropometrical and biochemical assessment protocol of the nutritional status. Neurological and genotype assessments were also performed.

RESULTS: A decrease in weight, body mass index (BMI), cutaneous skinfold thickness, fat mass, arm muscle circumference, calf circumference and skeletal muscle mass was observed in SCA2 patients compared to the controls. The total/HDL cholesterol ratio was significantly reduced in patients. BMI was correlated with the age at onset. Overall, anthropometric measures were correlated with clinical markers of disease severity and were more evident in severe and moderate cases.

CONCLUSIONS: Using anthropometric measures in the assessment of the nutritional status of SCA2 patients might provide hints about pathophysiological mechanisms that underlie metabolic abnormalities in SCA2. Anthropometric are close related with disease severity and progression, and trigger preventive therapies aimed to ameliorate weight loss and wasting in these patients.

Keywords: Spinocerebellar ataxia type 2; ataxin-2; biomarkers; body fat; body mass index; fat and muscle mass loss; skeletal muscle mass; weight loss

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