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Trends Endocrinol Metab. 2021 Jun;32(6):338-340. doi: 10.1016/j.tem.2021.03.001. Epub 2021 Mar 23.

Growth Hormone Releasing Hormone in Endothelial Barrier Function.

Trends in endocrinology and metabolism: TEM

Nektarios Barabutis

Affiliations

  1. School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA. Electronic address: [email protected].

PMID: 33771415 PMCID: PMC8102361 DOI: 10.1016/j.tem.2021.03.001

Abstract

Growth hormone releasing hormone (GHRH) is the integral regulator of the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis. It exerts mitogenic effects in a plethora of progressive cancers. Recent evidence suggests the emerging role of that 44-amino acid (aa) neuropeptide in lung endothelial barrier function (EBF), which will be discussed herein.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: acute lung injury; acute respiratory distress syndrome; sepsis

Conflict of interest statement

Declaration of Interests The author declares no conflicts of interest.

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