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Yoo KH, Tang JJ, Rashid MA, et al. Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments. Cancer Res. 2021;81(13):3727-3737doi: 10.1158/0008-5472.CAN-20-3290.
Yoo, K. H., Tang, J. J., Rashid, M. A., Cho, C. H., Corujo-Ramirez, A., Choi, J., Bae, M. G., Brogren, D., Hawse, J. R., Hou, X., Weroha, S. J., Oliveros, A., Kirkeby, L. A., Baur, J. A., & Jang, M. H. (2021). Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments. Cancer research, 81(13), 3727-3737. https://doi.org/10.1158/0008-5472.CAN-20-3290
Yoo, Ki Hyun, et al. "Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments." Cancer research vol. 81,13 (2021): 3727-3737. doi: https://doi.org/10.1158/0008-5472.CAN-20-3290
Yoo KH, Tang JJ, Rashid MA, Cho CH, Corujo-Ramirez A, Choi J, Bae MG, Brogren D, Hawse JR, Hou X, Weroha SJ, Oliveros A, Kirkeby LA, Baur JA, Jang MH. Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments. Cancer Res. 2021 Jul 01;81(13):3727-3737. doi: 10.1158/0008-5472.CAN-20-3290. Epub 2021 Mar 26. PMID: 33771896; PMCID: PMC8277702.
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Cancer Res. 2021 Jul 01;81(13):3727-3737. doi: 10.1158/0008-5472.CAN-20-3290. Epub 2021 Mar 26.

Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments.

Cancer research

Ki Hyun Yoo, Jason J Tang, Mohammad Abdur Rashid, Chang Hoon Cho, Ana Corujo-Ramirez, Jonghoon Choi, Mun Gyeong Bae, Danielle Brogren, John R Hawse, Xiaonan Hou, S John Weroha, Alfredo Oliveros, Lindsey A Kirkeby, Joseph A Baur, Mi-Hyeon Jang

Affiliations

  1. Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
  2. The Mayo Clinic Post-Baccalaureate Research Education Program (PREP), Rochester, Minnesota.
  3. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
  4. Department of Oncology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  5. Center for Regenerative Medicine Biotrust, Mayo Clinic, Rochester, Minnesota.
  6. Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  7. Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota. [email protected].

PMID: 33771896 PMCID: PMC8277702 DOI: 10.1158/0008-5472.CAN-20-3290

Abstract

Chemotherapy-induced cognitive impairment (CICI) is often reported as a neurotoxic side effect of chemotherapy. Although CICI has emerged as a significant medical problem, meaningful treatments are not currently available due to a lack of mechanistic understanding underlying CICI pathophysiology. Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD

©2021 American Association for Cancer Research.

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