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Hirschhäuser C, Lissoni A, Görge PM, et al. Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning. Basic Res Cardiol. 2021;116(1):21doi: 10.1007/s00395-021-00861-z.
Hirschhäuser, C., Lissoni, A., Görge, P. M., Lampe, P. D., Heger, J., Schlüter, K. D., Leybaert, L., Schulz, R., & Boengler, K. (2021). Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning. Basic research in cardiology, 116(1), 21. https://doi.org/10.1007/s00395-021-00861-z
Hirschhäuser, Christine, et al. "Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning." Basic research in cardiology vol. 116,1 (2021): 21. doi: https://doi.org/10.1007/s00395-021-00861-z
Hirschhäuser C, Lissoni A, Görge PM, Lampe PD, Heger J, Schlüter KD, Leybaert L, Schulz R, Boengler K. Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning. Basic Res Cardiol. 2021 Mar 22;116(1):21. doi: 10.1007/s00395-021-00861-z. PMID: 33751227; PMCID: PMC7985055.
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Basic Res Cardiol. 2021 Mar 22;116(1):21. doi: 10.1007/s00395-021-00861-z.

Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning.

Basic research in cardiology

Christine Hirschhäuser, Alessio Lissoni, Philipp Maximilian Görge, Paul D Lampe, Jacqueline Heger, Klaus-Dieter Schlüter, Luc Leybaert, Rainer Schulz, Kerstin Boengler

Affiliations

  1. Institut für Physiologie, Justus-Liebig Universität Gießen, Aulweg 129, 35392, Giessen, Germany.
  2. Department of Basic Medical Sciences, Physiology group, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
  3. Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  4. Institut für Physiologie, Justus-Liebig Universität Gießen, Aulweg 129, 35392, Giessen, Germany. [email protected].

PMID: 33751227 PMCID: PMC7985055 DOI: 10.1007/s00395-021-00861-z

Abstract

Myocardial connexin 43 (Cx43) forms gap junctions and hemichannels, and is also present within subsarcolemmal mitochondria. The protein is phosphorylated by several kinases including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and casein kinase 1 (CK1). A reduction in Cx43 content abrogates myocardial infarct size reduction by ischemic preconditioning (IPC). The present study characterizes the contribution of Cx43 phosphorylation towards mitochondrial function, hemichannel activity, and the cardioprotection by IPC in wild-type (WT) mice and in mice in which Cx43-phosphorylation sites targeted by above kinases are mutated to non-phosphorylatable residues (Cx43

Keywords: Connexin; Hemichannel; Ischemia/reperfusion; Ischemic preconditioning; Mitochondria; Phosphorylation

References

  1. Biochim Biophys Acta. 2008 May;1778(5):1206-12 - PubMed
  2. Circ Res. 2006 Jun 23;98(12):1498-505 - PubMed
  3. Basic Res Cardiol. 2018 Aug 17;113(5):39 - PubMed
  4. Cell Physiol Biochem. 2017;44(3):982-997 - PubMed
  5. Adv Exp Med Biol. 2017;982:169-189 - PubMed
  6. Mol Cell Proteomics. 2015 Nov;14(11):3040-55 - PubMed
  7. Circ Res. 2004 Oct 1;95(7):726-33 - PubMed
  8. Free Radic Biol Med. 2018 Mar;117:76-89 - PubMed
  9. Circulation. 2010 May 11;121(18):2012-22 - PubMed
  10. Basic Res Cardiol. 2003 May;98(3):181-2 - PubMed
  11. Pflugers Arch. 1993 Apr;423(1-2):158-60 - PubMed
  12. Circ Res. 2012 Jul 6;111(2):201-11 - PubMed
  13. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1714-20 - PubMed
  14. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1740-2 - PubMed
  15. J Cell Biol. 2007 Dec 17;179(6):1301-9 - PubMed
  16. Basic Res Cardiol. 2013 Jan;108(1):309 - PubMed
  17. FASEB J. 2010 Nov;24(11):4378-95 - PubMed
  18. Pharmacol Ther. 2015 Sep;153:90-106 - PubMed
  19. Circ Res. 2005 Oct 28;97(9):916-21 - PubMed
  20. Basic Res Cardiol. 2013 May;108(3):351 - PubMed
  21. J Bioenerg Biomembr. 2017 Oct;49(5):357-368 - PubMed
  22. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2106-12 - PubMed
  23. Br J Pharmacol. 2017 Jul;174(13):2060-2073 - PubMed
  24. J Cardiovasc Dis Res. 2011 Oct;2(4):206-12 - PubMed
  25. Circ Res. 2015 Feb 13;116(4):674-99 - PubMed
  26. Biomed Rep. 2015 Sep;3(5):668-674 - PubMed
  27. Cardiovasc Res. 2012 May 1;94(2):168-80 - PubMed
  28. Oncotarget. 2016 Oct 25;7(43):69243-69255 - PubMed
  29. Mol Med Rep. 2015 Jun;11(6):4720-6 - PubMed
  30. J Am Coll Cardiol. 2003 Feb 19;41(4):681-6 - PubMed
  31. Cell Biosci. 2016 Apr 14;6:25 - PubMed
  32. Biochim Biophys Acta. 2009 Jul;1787(7):794-801 - PubMed
  33. J Neurosci. 2017 Sep 13;37(37):9064-9075 - PubMed
  34. Cardiovasc Res. 2016 Mar 1;109(3):385-96 - PubMed
  35. Int J Mol Sci. 2020 Dec 29;22(1): - PubMed
  36. Sci Rep. 2017 Jun 6;7(1):2840 - PubMed
  37. Basic Res Cardiol. 2014;109(5):433 - PubMed
  38. J Biol Chem. 2002 Nov 22;277(47):44962-8 - PubMed
  39. Nat Rev Cardiol. 2020 Dec;17(12):773-789 - PubMed
  40. J Clin Invest. 2020 Apr 1;130(4):1713-1727 - PubMed
  41. J Cell Mol Med. 2012 Aug;16(8):1649-55 - PubMed
  42. Cardiovasc Res. 2015 May 1;106(2):227-36 - PubMed
  43. Circ Res. 2010 May 28;106(10):1592-602 - PubMed
  44. J Mol Cell Cardiol. 2017 Jun;107:52-57 - PubMed
  45. Int J Mol Sci. 2018 Jun 04;19(6): - PubMed
  46. Biochim Biophys Acta. 2005 Jun 10;1711(2):215-24 - PubMed
  47. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1215-H1231 - PubMed
  48. Sci Rep. 2019 Sep 19;9(1):13543 - PubMed
  49. J Biol Chem. 2019 Aug 2;294(31):11762-11771 - PubMed
  50. Biochim Biophys Acta. 2004 Mar 23;1662(1-2):61-80 - PubMed
  51. Pflugers Arch. 2010 Sep;460(4):731-41 - PubMed
  52. Circ Res. 2006 Jul 7;99(1):93-101 - PubMed
  53. J Cell Sci. 2014 Jan 15;127(Pt 2):455-64 - PubMed
  54. FASEB J. 2003 Jul;17(10):1355-7 - PubMed
  55. Front Pharmacol. 2013 Jun 06;4:73 - PubMed
  56. Circ Res. 2005 Sep 16;97(6):583-6 - PubMed
  57. Circ Res. 2011 Jun 10;108(12):1459-66 - PubMed
  58. BMC Cell Biol. 2016 May 24;17 Suppl 1:11 - PubMed
  59. J Cell Sci. 2006 Aug 15;119(Pt 16):3435-42 - PubMed
  60. J Biol Chem. 1999 Jan 1;274(1):236-40 - PubMed
  61. Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1115-25 - PubMed
  62. Basic Res Cardiol. 2006 Jul;101(4):354-6 - PubMed
  63. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5934-E5943 - PubMed
  64. J Mol Cell Cardiol. 2004 Jan;36(1):161-3 - PubMed
  65. J Exp Med. 2019 Apr 1;216(4):916-935 - PubMed
  66. Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):83-90 - PubMed
  67. Cardiovasc Res. 2009 Sep 1;83(4):672-81 - PubMed
  68. Basic Res Cardiol. 2017 May;112(3):27 - PubMed
  69. Cardiovasc Res. 2014 Jul 1;103(1):72-80 - PubMed
  70. J Mol Cell Cardiol. 2006 Jun;40(6):790-8 - PubMed
  71. J Biol Chem. 2004 May 7;279(19):20058-66 - PubMed
  72. Cardiovasc Pathol. 2002 May-Jun;11(3):158-65 - PubMed
  73. J Mol Cell Cardiol. 2004 Jan;36(1):101-10 - PubMed
  74. Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H698-703 - PubMed
  75. J Neurosci. 2008 Apr 30;28(18):4702-11 - PubMed
  76. Cardiovasc Res. 2010 Nov 1;88(2):277-86 - PubMed
  77. Cardiovasc Res. 2021 Jan 1;117(1):123-136 - PubMed
  78. Nat Rev Mol Cell Biol. 2003 Apr;4(4):285-94 - PubMed
  79. Biochim Biophys Acta. 2011 Jul;1813(7):1286-94 - PubMed
  80. Int J Mol Sci. 2013 Jan 24;14(2):2242-57 - PubMed
  81. Basic Res Cardiol. 2009 Mar;104(2):141-7 - PubMed
  82. Adv Exp Med Biol. 2017;982:227-246 - PubMed

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