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Dai L, Zhang J, Wong CT, et al. Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics. Inorg Chem. 2021;60(10):7082-7088doi: 10.1021/acs.inorgchem.0c03734.
Dai, L., Zhang, J., Wong, C. T., Chan, W. T. K., Ling, X., Anderson, C. J., & Law, G. L. (2021). Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics. Inorganic chemistry, 60(10), 7082-7088. https://doi.org/10.1021/acs.inorgchem.0c03734
Dai, Lixiong, et al. "Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics." Inorganic chemistry vol. 60,10 (2021): 7082-7088. doi: https://doi.org/10.1021/acs.inorgchem.0c03734
Dai L, Zhang J, Wong CT, Chan WTK, Ling X, Anderson CJ, Law GL. Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics. Inorg Chem. 2021 May 17;60(10):7082-7088. doi: 10.1021/acs.inorgchem.0c03734. Epub 2021 Mar 09. PMID: 33689299.
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Inorg Chem. 2021 May 17;60(10):7082-7088. doi: 10.1021/acs.inorgchem.0c03734. Epub 2021 Mar 09.

Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics.

Inorganic chemistry

Lixiong Dai, Junhui Zhang, Carlos Tinlong Wong, Wesley Ting Kwok Chan, Xiaoxi Ling, Carolyn J Anderson, Ga-Lai Law

Affiliations

  1. Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom 999077, Hong Kong SAR.
  2. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
  3. Departments of Medicine, Radiology, Pharmacology and Chemical Biology, Chemistry, and Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
  4. Departments of Chemistry and Radiology, University of Missouri, Columbia, Missouri 65211, United States.

PMID: 33689299 DOI: 10.1021/acs.inorgchem.0c03734

Abstract

A series of water-soluble chiral cyclen-based chelators with chemical handles for selective targeting have been synthesized (cyclen = 1,4,7,10-Tetraazacyclododecane). Optical studies, relaxivity measurements, and competitive titrations were performed to show the versatility of these chiral chelators. The complexations of L3, L4, and L5 with Lu

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